Intrahepatic paracrine signaling by CLCF1 ameliorates diet-induced NASH in mice.
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32719
Abstract: The mammalian liver harbors heterogeneous cell types that communicate via local paracrine signaling. Recent studies have delineated the transcriptomic landscape of the liver in nonalcoholic steatohepatitis (NASH) that provides insights into liver cell heterogeneity, intercellular… read more here.
Keywords: induced nash; paracrine signaling; clcf1; diet induced ... See more keywords
Ferroptosis mediated by the interaction between Mfn2 and IREα promotes arsenic-induced nonalcoholic steatohepatitis.
Sign Up to like & getrecommendations! Published in 2020 at "Environmental research"
DOI: 10.1016/j.envres.2020.109824
Abstract: Exposure to arsenic is a risk factor for nonalcoholic steatohepatitis (NASH). Ferroptosis is a form of regulated cell death defined by the accumulation of lipid peroxidation. In the current study, we observed the occurrence of… read more here.
Keywords: mfn2; nonalcoholic steatohepatitis; ferroptosis; arsenic induced ... See more keywords
Mitochondrial protease ClpP supplementation ameliorates diet-induced NASH in mice.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2022.03.034
Abstract: BACKGROUND & AIMS Mitochondrial dysfunction is considered a pathogenic linker in the development of non-alcoholic steatohepatitis (NASH). Inappropriate mitochondrial protein-quality control, possibly induced due to insufficiency of the mitochondrial matrix caseinolytic protease P (ClpP), can… read more here.
Keywords: mice; mitochondrial dysfunction; induced nash; clpp ... See more keywords