A small molecule inhibitor screen reveals calcium channel signaling as a mechanistic mediator of Clostridium difficile TcdB-induced necrosis.
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DOI: 10.1021/acschembio.9b00906
Abstract: Clostridiodes difficile is the leading cause of nosocomial diarrhea in the United States. The primary virulence factors are two homologous glucosyltransferase toxins, TcdA and TcdB, that inactivate host Rho-family GTPases. The glucosyltransferase activity has been… read more here.
Keywords: small molecule; screen; tcdb; tcdb induced ... See more keywords