New insights into the vancomycin‐induced nephrotoxicity using in vitro metabolomics combined with physiologically based pharmacokinetic modeling
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.3951
Abstract: Vancomycin is a first‐line treatment for invasive infections caused by multidrug‐resistant gram‐positive bacteria. However, vancomycin‐induced nephrotoxicity is an increasing burden, particularly in patients with complex life‐threatening conditions. Vancomycin‐induced nephrotoxicity associated with clinically relevant exposure on… read more here.
Keywords: vancomycin; based pharmacokinetic; induced nephrotoxicity; physiologically based ... See more keywords
Clemizole hydrochloride, a potent TRPC5 calcium channel inhibitor, prevents cisplatin-induced nephrotoxicity in Spraque-Dawley rats.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.23372
Abstract: Cis-diamminedichloroplatinum (II) (cisplatin, Cis) is widely employed to treat several types of cancer. It has many important toxic side effects; one of the most important of which is nephrotoxicity. Clemizole hydrochloride (Clem) as the most… read more here.
Keywords: clem; clemizole hydrochloride; doses clem; cis ... See more keywords
Renal transporter OAT1 and PPAR‐α pathway co‐contribute to icaritin‐induced nephrotoxicity
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7633
Abstract: This study aimed to investigate the potential nephrotoxicity of icaritin and the underlying mechanism by in vitro–in vivo experiment technology combined with proteomics technology. First, icaritin showed a significant cytotoxic effect on HK‐2 cells, which… read more here.
Keywords: ppar; icaritin induced; renal transporter; icaritin ... See more keywords
Tanshinone IIA prevents acetaminophen‐induced nephrotoxicity through the activation of the Nrf2‐Mrp2/4 pathway in mice
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23511
Abstract: It's known that APAP overdose often leads to hepatotoxicity and nephrotoxicity. In the present study, we investigated the preventative effect of Tan IIA on APAP‐induced nephrotoxicity. Mice were orally administrated with Tan IIA (10 or… read more here.
Keywords: nrf2 mrp2; iia; tan iia; mice ... See more keywords
TNF-α, IL-6 and IL-10 expressions, responsible for disparity in action of curcumin against cisplatin-induced nephrotoxicity in rats
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-017-2981-5
Abstract: Cisplatin is a regularly employed effective chemotherapeutic agent for the treatment of many types of cancer. The main drawback of cisplatin treatment is kidney toxicity which affects 25–35% of treated patients. Many mechanisms are believed… read more here.
Keywords: induced nephrotoxicity; treatment; cisplatin; cisplatin induced ... See more keywords
Evaluation of the effect of acetazolamide versus mannitol on cisplatin-induced nephrotoxicity, a pilot study
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Clinical Pharmacy"
DOI: 10.1007/s11096-018-0677-x
Abstract: Background Cisplatin-induced nephrotoxicity still occurs despite the intensive hydration approach adapted to prevent its occurrence. Objective Evaluation of the effect of acetazolamide (ACTZ) on minimizing cisplatin-induced nephrotoxicity compared to mannitol when added to hydration regimen.… read more here.
Keywords: induced nephrotoxicity; cisplatin; effect; cisplatin induced ... See more keywords
Bendiocarb-induced nephrotoxicity in rats and the protective role of vitamins C and E
Sign Up to like & getrecommendations! Published in 2019 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-019-07260-x
Abstract: Bendiocarb is a pesticide carbamate which is used to protect agricultural products and animals. In this study, rats were given orally with bendiocarb and also other chemicals via gavage. Male rats were randomly divided into… read more here.
Keywords: induced nephrotoxicity; bendiocarb vitamin; bendiocarb induced; group ... See more keywords
Silver nanoparticles-induced nephrotoxicity in rats: the protective role of red beetroot (Beta vulgaris) juice
Sign Up to like & getrecommendations! Published in 2020 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-020-09671-7
Abstract: The present study was designed to investigate the nephrotoxicity of silver nanoparticles (AgNPs; 80 mg/kg; > 100 nm) and to evaluate the protective effect exercised by Beta vulgaris (beetroot) juice (RBR; 200 mg/kg) on male rats’… read more here.
Keywords: silver nanoparticles; nephrotoxicity; induced nephrotoxicity; beta vulgaris ... See more keywords
The multitargeted kinase inhibitor KW-2449 ameliorates cisplatin-induced nephrotoxicity by targeting RIPK1-mediated necroptosis.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2021.114542
Abstract: Cisplatin (cis-dichloro-diammine platinum, CDDP) is a well-known chemotherapeutic drug against a broad spectrum of human malignancies. However, the clinical utility of this effective chemotherapy agent is dose limited by its toxic side effects such as… read more here.
Keywords: inhibitor; induced nephrotoxicity; kinase; cisplatin ... See more keywords
A nephron model for study of drug-induced acute kidney injury and assessment of drug-induced nephrotoxicity.
Sign Up to like & getrecommendations! Published in 2018 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2017.11.010
Abstract: In this study, we developed a multilayer microfluidic device to simulate nephron, which was formed by "glomerulus", "Bowman's capsule", "proximal tubular lumen" and "peritubular capillary". In this microdevice, artificial renal blood flow was circulating and… read more here.
Keywords: assessment drug; induced nephrotoxicity; drug induced; drug ... See more keywords
Renoprotective effect of celecoxib against gentamicin-induced nephrotoxicity through suppressing NFκB and caspase-3 signaling pathways in rats.
Sign Up to like & getrecommendations! Published in 2019 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2019.108863
Abstract: Gentamicin-induced nephrotoxicity has been well documented, although the causing mechanisms and preventative measures need further investigation. The current study aimed to explore the potential protective impacts of celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, on gentamicin-induced… read more here.
Keywords: protein; celecoxib; gentamicin; induced nephrotoxicity ... See more keywords