New insights into the vancomycin‐induced nephrotoxicity using in vitro metabolomics combined with physiologically based pharmacokinetic modeling
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.3951
Abstract: Vancomycin is a first‐line treatment for invasive infections caused by multidrug‐resistant gram‐positive bacteria. However, vancomycin‐induced nephrotoxicity is an increasing burden, particularly in patients with complex life‐threatening conditions. Vancomycin‐induced nephrotoxicity associated with clinically relevant exposure on… read more here.
Keywords: vancomycin; based pharmacokinetic; induced nephrotoxicity; physiologically based ... See more keywords
Clemizole hydrochloride, a potent TRPC5 calcium channel inhibitor, prevents cisplatin-induced nephrotoxicity in Spraque-Dawley rats.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.23372
Abstract: Cis-diamminedichloroplatinum (II) (cisplatin, Cis) is widely employed to treat several types of cancer. It has many important toxic side effects; one of the most important of which is nephrotoxicity. Clemizole hydrochloride (Clem) as the most… read more here.
Keywords: clem; clemizole hydrochloride; doses clem; cis ... See more keywords
Methyl Donor Ameliorates CCl4‐Induced Nephrotoxicity by Inhibiting Oxidative Stress, Inflammation, and Fibrosis Through the Attenuation of Kidney Injury Molecule 1 and Neutrophil Gelatinase‐Associated Lipocalin Expression
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.70188
Abstract: Carbon tetrachloride (CCl4), a volatile organic compound, is harmful to multi‐organs, including the liver, lungs, muscles, and kidneys. Methyl donors, such as methionine, choline, betaine, and folic acid, are vital to one‐carbon metabolism and have… read more here.
Keywords: methyl donor; ccl4 induced; induced nephrotoxicity; oxidative stress ... See more keywords
Exploring the Mechanisms of Lead (II)-Induced Nephrotoxicity via Integrative Bioinformatics Analysis.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.70628
Abstract: Lead (Pb), a pervasive environmental toxicant, exerts substantial nephrotoxic effects in mammalian organisms. However, the molecular mechanisms underlying Pb‐induced renal toxicity remain poorly elucidated. In this study, we employed an integrative bioinformatics approach to identify… read more here.
Keywords: mechanisms lead; integrative bioinformatics; induced nephrotoxicity; analysis ... See more keywords
Renal transporter OAT1 and PPAR‐α pathway co‐contribute to icaritin‐induced nephrotoxicity
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7633
Abstract: This study aimed to investigate the potential nephrotoxicity of icaritin and the underlying mechanism by in vitro–in vivo experiment technology combined with proteomics technology. First, icaritin showed a significant cytotoxic effect on HK‐2 cells, which… read more here.
Keywords: ppar; icaritin induced; renal transporter; icaritin ... See more keywords
Tanshinone IIA prevents acetaminophen‐induced nephrotoxicity through the activation of the Nrf2‐Mrp2/4 pathway in mice
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23511
Abstract: It's known that APAP overdose often leads to hepatotoxicity and nephrotoxicity. In the present study, we investigated the preventative effect of Tan IIA on APAP‐induced nephrotoxicity. Mice were orally administrated with Tan IIA (10 or… read more here.
Keywords: nrf2 mrp2; iia; tan iia; mice ... See more keywords
Tetrahydrocurcumin Attenuates Polymyxin B Sulfate‐Induced HK‐2 Cells Apoptosis by Inhibiting Endoplasmic Reticulum Stress‐Mediated PERK/eIF2α/ATF4/CHOP Signaling Pathway Axis
Sign Up to like & getrecommendations! Published in 2024 at "Environmental Toxicology"
DOI: 10.1002/tox.24376
Abstract: The clinical application of polymyxin B (PMB) is limited by its nephrotoxic effects, making the reduction of PMB‐induced nephrotoxicity has become a pressing concern for clinicians. Tetrahydrocurcumin (THC), known for its beneficial characteristics in biological… read more here.
Keywords: induced nephrotoxicity; stress; eif2 atf4; pmb ... See more keywords
Clopidogrel protects against gentamicin-induced nephrotoxicity through targeting oxidative stress, apoptosis, and coagulation pathways
Sign Up to like & getrecommendations! Published in 2024 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-024-03380-5
Abstract: Gentamicin (Genta)-induced nephrotoxicity poses a significant clinical challenge due to its detrimental effects on kidney function. Clopidogrel (Clop), an antiplatelet drug known for its ability to prevent blood clots by inhibiting platelet aggregation, also has… read more here.
Keywords: genta induced; induced nephrotoxicity; oxidative stress;
Oxyresveratrol and/or Dapagliflozin Attenuate Doxorubicin-Induced Nephrotoxicity via Modulation of PPAR-γ/Nrf-2/HO-1, NF-κB/TNF-α/Keap-1, and Bcl-2/Caspase-3/ATG-5 signaling pathways in rats
Sign Up to like & getrecommendations! Published in 2024 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-024-03608-4
Abstract: Among the most undesirable effects that lead to the restriction of doxorubicin (DOX) use in chemotherapy is kidney damage. This research aimed to assess the possible defenses against DOX-induced nephrotoxicity offered by oxyresveratrol (ORES) and/or… read more here.
Keywords: kidney; ppar; induced nephrotoxicity; caspase ... See more keywords
TNF-α, IL-6 and IL-10 expressions, responsible for disparity in action of curcumin against cisplatin-induced nephrotoxicity in rats
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-017-2981-5
Abstract: Cisplatin is a regularly employed effective chemotherapeutic agent for the treatment of many types of cancer. The main drawback of cisplatin treatment is kidney toxicity which affects 25–35% of treated patients. Many mechanisms are believed… read more here.
Keywords: induced nephrotoxicity; treatment; cisplatin; cisplatin induced ... See more keywords
Evaluation of the effect of acetazolamide versus mannitol on cisplatin-induced nephrotoxicity, a pilot study
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Clinical Pharmacy"
DOI: 10.1007/s11096-018-0677-x
Abstract: Background Cisplatin-induced nephrotoxicity still occurs despite the intensive hydration approach adapted to prevent its occurrence. Objective Evaluation of the effect of acetazolamide (ACTZ) on minimizing cisplatin-induced nephrotoxicity compared to mannitol when added to hydration regimen.… read more here.
Keywords: induced nephrotoxicity; cisplatin; effect; cisplatin induced ... See more keywords