IL‐10 and Cdc42 modulate astrocyte‐mediated microglia activation in methamphetamine‐induced neuroinflammation
Sign Up to like & getrecommendations! Published in 2024 at "Glia"
DOI: 10.1002/glia.24542
Abstract: Methamphetamine (Meth) use is known to induce complex neuroinflammatory responses, particularly involving astrocytes and microglia. Building upon our previous research, which demonstrated that Meth stimulates astrocytes to release tumor necrosis factor (TNF) and glutamate, leading… read more here.
Keywords: astrocyte; activation; methamphetamine; cdc42 ... See more keywords
Cyclooxygenase Inhibitor 4-Methylthiazole Derivative Compound Alleviates Lipopolysaccharides-Induced Neuroinflammation in Male Rats With Regulating Cytokine Levels.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.70620
Abstract: The development of neurological diseases is an important but poorly understood condition around worldwide. Therefore, treatment options remain quite limited. This study looked into how lipopolysaccharide (LPS)‐induced neuroinflammation was affected in vivo by the cyclooxygenase… read more here.
Keywords: inhibitor methylthiazole; neuroinflammation; compound; induced neuroinflammation ... See more keywords
Pterostilbene inhibits amyloid‐β‐induced neuroinflammation in a microglia cell line by inactivating the NLRP3/caspase‐1 inflammasome pathway
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27023
Abstract: Neuroinflammation has been known as an important pathogenetic contributor of Alzheimer's disease (AD). Pterostilbene is a natural compound which has neuroprotective activity. However, the effect of pterostilbene on amyloid‐β (Aβ)‐induced neuroinflammation has not been clarified.… read more here.
Keywords: nlrp3 caspase; caspase inflammasome; neuroinflammation; induced neuroinflammation ... See more keywords
In vitro models to study insulin and glucocorticoids modulation of trimethyltin (TMT)-induced neuroinflammation and neurodegeneration, and in vivo validation in db/db mice
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Toxicology"
DOI: 10.1007/s00204-019-02455-0
Abstract: Brain susceptibility to a neurotoxic insult may be increased in a compromised health status, such as metabolic syndrome. Both metabolic syndrome and exposure to trimethyltin (TMT) are known to promote neurodegeneration. In combination the two… read more here.
Keywords: tmt induced; tmt; exposure; induced neuroinflammation ... See more keywords
Trans-cinnamaldehyde Modulates Hippocampal Nrf2 Factor and Inhibits Amyloid Beta Aggregation in LPS-Induced Neuroinflammation Mouse Model
Sign Up to like & getrecommendations! Published in 2018 at "Neurochemical Research"
DOI: 10.1007/s11064-018-2656-y
Abstract: Trans-cinnamaldehyde (CNM) has recently drawn attention due to its potent anti-inflammatory and antioxidant properties. The current study explored the memory enhancing effects of CNM against lipopolysaccharide (LPS)-induced neuroinflammation in mice. CNM and curcumin (a reference… read more here.
Keywords: trans cinnamaldehyde; lps induced; neuroinflammation; induced neuroinflammation ... See more keywords
Depletion of brain perivascular macrophages regulates acute restraint stress-induced neuroinflammation and oxidative/nitrosative stress in rat frontal cortex
Sign Up to like & getrecommendations! Published in 2020 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2020.03.004
Abstract: The central nervous system can respond to peripheral immune stimuli through the activation of the neurovascular unit. One of the cellular types implicated are perivascular macrophages (PVMs), hematopoietic-derived brain-resident cells located in the perivascular space.… read more here.
Keywords: neuroinflammation oxidative; induced neuroinflammation; stress induced; stress ... See more keywords
Vitexin inhibits acrylamide-induced neuroinflammation and improves behavioral changes in zebrafish larvae.
Sign Up to like & getrecommendations! Published in 2019 at "Neurotoxicology and teratology"
DOI: 10.1016/j.ntt.2019.106811
Abstract: Neuroinflammation is crucial for the pathophysiological hallmarks of many neurodegenerative disorders. Hyperactivated microglia has long been implicated as a detrimental player in regulating unresolvable inflammatory insults which cause damage to neurons. In the context of… read more here.
Keywords: zebrafish larvae; vitexin; induced neuroinflammation; larvae ... See more keywords
Role of cannabinoids in alcohol-induced neuroinflammation
Sign Up to like & getrecommendations! Published in 2021 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"
DOI: 10.1016/j.pnpbp.2020.110054
Abstract: Alcohol is a psychoactive substance highly used worldwide, whose harmful use might cause a broad range of mental and behavioural disorders. Underlying brain impact, the neuroinflammatory response induced by alcohol is recognised as a key… read more here.
Keywords: anti inflammatory; endocannabinoid system; induced neuroinflammation; alcohol induced ... See more keywords
Role of the Peli1-RIPK1 Signaling Axis in Methamphetamine-Induced Neuroinflammation.
Sign Up to like & getrecommendations! Published in 2023 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00623
Abstract: Severe neurological inflammation is one of the main symptoms of methamphetamine (meth)-induced brain injury. Studies have demonstrated that meth exposure facilitates neuroinflammation via Pellino E3 ubiquitin protein ligase 1 (Peli1)-mediated signaling. However, the involved mechanisms… read more here.
Keywords: meth induced; induced neuroinflammation; peli1 ripk1; peli1 ... See more keywords
Glial cell diversity and methamphetamine-induced neuroinflammation in human cerebral organoids
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Psychiatry"
DOI: 10.1038/s41380-020-0676-x
Abstract: Methamphetamine (METH) is a potent stimulant that induces a euphoric state but also causes cognitive impairment, neurotoxicity and neurodevelopmental deficits. Yet, the molecular mechanisms by which METH causes neurodevelopmental defects have remained elusive. Here we… read more here.
Keywords: methamphetamine; induced neuroinflammation; cerebral organoids; human cerebral ... See more keywords
Forkhead Box 1(FoxO1) mediates psychological stress-induced neuroinflammation
Sign Up to like & getrecommendations! Published in 2022 at "Neurological Research"
DOI: 10.1080/01616412.2021.2022913
Abstract: ABSTRACT Objectives Neuroinflammation plays a key role in cerebrovascular disease (CVD). Neuropsychiatric disorders appear to share an epidemiological association with inflammation, but the mechanisms are unclear. Forkhead box 1 (FoxO1) regulates inflammatory signaling in diabetes… read more here.
Keywords: stress; forkhead box; induced neuroinflammation; stress induced ... See more keywords