In Vitro Direct Reprogramming of Mouse and Human Astrocytes to Induced Neurons.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0655-1_4
Abstract: Direct neuronal reprogramming, rewiring the epigenetic and transcriptional network of a differentiated cell type to neuron, apart from being a very promising approach for the treatment of brain injury and neurodegeneration, also offers a prime… read more here.
Keywords: neurons vitro; induced neurons; mouse human; human astrocytes ... See more keywords
Reprogramming of Rat Fibroblasts into Induced Neurons by Small-Molecule Compounds In Vitro and In Vivo.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00078
Abstract: Cell replacement is a promising approach for neurodegenerative disease treatment. Somatic cells such as fibroblasts can be induced to differentiate into neurons by specific transcription factors; however, the potential of viral vectors used for reprogramming… read more here.
Keywords: small molecule; marker; rat; molecule compounds ... See more keywords
Transcriptional signature of induced neurons differentiates virologically suppressed people with HIV from people without HIV.
Sign Up to like & getrecommendations! Published in 2025 at "JCI insight"
DOI: 10.1172/jci.insight.190445
Abstract: Neurocognitive impairment is a prevalent co-morbidity in virologically suppressed people living with HIV (PLWH), yet the underlying mechanisms remain elusive and treatments lacking. We explored use of participant-derived directly induced neurons (iNs) to model neuronal… read more here.
Keywords: plwh; people without; induced neurons; virologically suppressed ... See more keywords