DNMT3a‐triggered downregulation of K2p1.1 gene in primary sensory neurons contributes to paclitaxel‐induced neuropathic pain
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Cancer"
DOI: 10.1002/ijc.32155
Abstract: Antineoplastic drugs induce dramatic transcriptional changes in dorsal root ganglion (DRG) neurons, which may contribute to chemotherapy‐induced neuropathic pain. K2p1.1 controls neuronal excitability by setting the resting membrane potential. Here, we report that systemic injection… read more here.
Keywords: k2p1; paclitaxel induced; dnmt3a; drg ... See more keywords
DNMT3b SUMOylation Mediated MMP-2 Upregulation Contribute to Paclitaxel Induced Neuropathic Pain.
Sign Up to like & getrecommendations! Published in 2021 at "Neurochemical research"
DOI: 10.1007/s11064-021-03260-x
Abstract: Paclitaxel is a common chemotherapeutic agent in cancer treatment, while it often causes chemotherapy-induced peripheral neuropathy (CIPN), which manifested as hyperalgesia and allodynia, and its mechanism remains largely unknown. The previous study has shown that matrix metalloproteinase-2 (MMP-2)… read more here.
Keywords: sumoylation; paclitaxel induced; induced neuropathic; neuropathic pain ... See more keywords
Evodiamine ameliorates paclitaxel-induced neuropathic pain by inhibiting inflammation and maintaining mitochondrial anti-oxidant functions
Sign Up to like & getrecommendations! Published in 2019 at "Human Cell"
DOI: 10.1007/s13577-019-00238-4
Abstract: Chemotherapy-induced neuropathic pain (CINP) is a common and debilitating side effect of cancer treatment. Evodiamine, a major effective compound isolated from Evodia rutaecarpa, has been associated with anti-inflammatory and anti-nociceptive effects, an important therapeutic strategy… read more here.
Keywords: paclitaxel induced; induced neuropathic; neuropathic pain; evodiamine ... See more keywords
Diabetes-induced Neuropathic Mechanical Hyperalgesia Depends on P2X4 Receptor Activation in Dorsal Root Ganglia
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2018.12.003
Abstract: Peripheral diabetic neuropathy (PDN) manifests in 50-60% of type I and II diabetic patients and is the major cause of limb amputation. Adequate therapy for PDN is a current challenge. There are evidences that the… read more here.
Keywords: mechanical hyperalgesia; induced neuropathic; neuropathic mechanical; p2x4r ... See more keywords
Hyperbaric oxygenation alleviates chronic constriction injury (CCI)-induced neuropathic pain and inhibits GABAergic neuron apoptosis in the spinal cord
Sign Up to like & getrecommendations! Published in 2017 at "Scandinavian Journal of Pain"
DOI: 10.1016/j.sjpain.2017.08.014
Abstract: Abstract Background and aims Dysfunction of GABAergic inhibitory controls contributes to the development of neuropathic pain. We examined our hypotheses that (1) chronic constriction injury (CCI)-induced neuropathic pain is associated with increased spinal GABAergic neuron… read more here.
Keywords: cci induced; apoptosis; induced neuropathic; neuropathic pain ... See more keywords
Sexually dimorphic therapeutic response in bortezomib-induced neuropathic pain reveals altered pain physiology in female rodents.
Sign Up to like & getrecommendations! Published in 2019 at "Pain"
DOI: 10.1097/j.pain.0000000000001697
Abstract: Chemotherapy-induced neuropathic pain (CINP) in both sexes compromises many current chemotherapeutics and lacks a FDA-approved therapy. We recently identified the sphingosine-1-phosphate receptor subtype 1 (S1PR1) and A3 adenosine receptor subtype (A3AR) as novel targets for… read more here.
Keywords: induced neuropathic; physiology; neuropathic pain; bortezomib induced ... See more keywords
Using Network Pharmacology and Animal Experiment to Investigate the Therapeutic Mechanisms of Polydatin against Vincristine-Induced Neuropathic Pain
Sign Up to like & getrecommendations! Published in 2022 at "Mediators of Inflammation"
DOI: 10.1155/2022/6010952
Abstract: Background Polydatin (PD) is the primary active compound in Polygonum cuspidatum Sieb and has been demonstrated to exert anti-inflammatory and neuroprotective activities. In the present study, we aimed to explore the therapeutic mechanisms of PD… read more here.
Keywords: network; induced neuropathic; pharmacology; neuropathic pain ... See more keywords
Oxaliplatin-loaded monomethoxy (polyethylene glycol)–poly(d, l-lactic-co-glycolic acid) nanoparticles induced neuropathic pain through the pro-inflammatory effect of microglia in the spinal dorsal horn mediated by Zic2/membrane adapter protein 12
Sign Up to like & getrecommendations! Published in 2020 at "Materials Express"
DOI: 10.1166/mex.2020.1771
Abstract: The aim of this study is to investigate the effect and mechanism of oxaliplatin (OX)-loaded monomethoxy (polyethylene glycol)–poly(d, l-lactic-co-glycolic acid) (mPEG–PLGA) nanoparticles on neuropathic pain induced by pro-inflammatory action of Zic2/membrane adaptor protein 12 (DAP12)… read more here.
Keywords: spinal dorsal; dorsal horn; induced neuropathic; zic2 ... See more keywords
A network approach to investigating the key microbes and stability of gut microbial communities in a mouse neuropathic pain model
Sign Up to like & getrecommendations! Published in 2020 at "BMC Microbiology"
DOI: 10.1186/s12866-020-01981-7
Abstract: Background Neuropathic pain is an abnormally increased sensitivity to pain, especially from mechanical or thermal stimuli. To date, the current pharmacological treatments for neuropathic pain are still unsatisfactory. The gut microbiota reportedly plays important roles… read more here.
Keywords: spared nerve; induced neuropathic; injury induced; neuropathic pain ... See more keywords
Chemotherapy-induced neuropathic pain characteristics in Mexico’s National Cancer Center pain clinic
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pain Research"
DOI: 10.2147/jpr.s186107
Abstract: Introduction: Chemotherapy (CT) is one of the most commonly used pharmacological approaches in cancer treatment. However, CT induces damage to several tissues causing significant deleterious effects in cancer survivors being chemotherapy-induced neuropathic pain (CINP) among… read more here.
Keywords: pain; chemotherapy induced; cancer; neuropathic pain ... See more keywords
Benzimidazole Derivative Ameliorates Opioid-mediated Tolerance during Anticancer-Induced Neuropathic Pain in mice.
Sign Up to like & getrecommendations! Published in 2020 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520620999200818155031
Abstract: BACKGROUND Cancer is known to be the second significant cause of death worldwide. Chemotherapeutic agents such as platinum-based compounds are frequently used single-handedly or accompanied with additional chemotherapies to treat cancer patients. Chemotherapy-inducedperipheral painful neuropathy… read more here.
Keywords: benzimidazole derivative; tolerance; induced neuropathic; mice ... See more keywords