Steroid-induced ocular hypertension/glaucoma: Focus on pharmacogenomics and implications for precision medicine
Sign Up to like & getrecommendations! Published in 2017 at "Progress in Retinal and Eye Research"
DOI: 10.1016/j.preteyeres.2016.09.003
Abstract: Elevation of intraocular pressure (IOP) due to therapeutic use of glucocorticoids is called steroid-induced ocular hypertension (SIOH); this can lead to steroid-induced glaucoma (SIG). Glucocorticoids initiate signaling cascades ultimately affecting expression of hundreds of genes;… read more here.
Keywords: medicine; precision medicine; induced ocular; ocular hypertension ... See more keywords
Copolymer Micelle-administered Melatonin Ameliorates Hyperosmolarity-induced Ocular Surface Damage through Regulating PINK1-mediated Mitophagy
Sign Up to like & getrecommendations! Published in 2022 at "Current Eye Research"
DOI: 10.1080/02713683.2021.2022163
Abstract: Abstract Purpose To investigate the role and mechanism of melatonin-loaded polymer polyvinyl caprolactam–polyvinyl acetate–polyethyleneglycol graft copolymer micelles (Mel-Mic) in dry eye disease (DED). Methods In vitro, the apoptosis and reactive oxygen species (ROS) generation in… read more here.
Keywords: induced ocular; ameliorates hyperosmolarity; hyperosmolarity induced; hyperosmolarity ... See more keywords
Combined Trabeculotomy-trabeculectomy versus Trabeculectomy for Treatment of Silicone Oil-induced Ocular Hypertension.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Glaucoma"
DOI: 10.1097/ijg.0000000000001702
Abstract: PRéCIS:: Combined trabeculotomy-trabeculectomy has a significantly better hypotensive effect than trabeculectomy and a higher success rate in cases of silicone oil-induced ocular hypertension. PURPOSE To compare the ocular hypotensive effect of combined trabeculotomy-trabeculectomy (CTT) with… read more here.
Keywords: trabeculectomy; ocular hypertension; silicone oil; oil ... See more keywords
Multicenter prospective observational study of dupilumab‐induced ocular events in atopic dermatitis patients
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DOI: 10.1111/jdv.18932
Abstract: Although ocular adverse events are frequent in AD patients treated with dupilumab, their characterization remains limited due to a lack of prospective studies with a systematic ophthalmological examination. read more here.
Keywords: multicenter prospective; induced ocular; observational study; study dupilumab ... See more keywords
Dupilumab-induced ocular surface disease: a primer
Sign Up to like & getrecommendations! Published in 2022 at "BMJ Case Reports"
DOI: 10.1136/bcr-2022-249019
Abstract: The management of atopic diseases has been revolutionised by precision therapies and biological drugs that target specific immune proteins. This report elucidates a unique complication from the use of the monoclonal antibody, dupilumab, that primary… read more here.
Keywords: disease; induced ocular; surface disease; dupilumab induced ... See more keywords
Therapeutic effects of proanthocyanidin and coenzyme Q10 on nitrogen mustard-induced ocular injury.
Sign Up to like & getrecommendations! Published in 2018 at "Arquivos brasileiros de oftalmologia"
DOI: 10.5935/0004-2749.20180045
Abstract: PURPOSE Nitrogen mustard (NM) is a devastating casualty agent in chemical warfare. There is no effective antidote to treat NM-induced ocular injury. We aimed to assess the effects of proanthocyanidin (PAC) and coenzyme Q10 (CoQ10)… read more here.
Keywords: induced ocular; group; pac coq10; ocular injury ... See more keywords