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   Articles with "induced osteolysis" as a keyword



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Emodin attenuates titanium particle‐induced osteolysis and RANKL‐mediated osteoclastogenesis through the suppression of IKK phosphorylation

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recommendations! Published in 2018 at "Molecular Immunology"

DOI: 10.1016/j.molimm.2018.02.008

Abstract: &NA; Aseptic loosening due to wear particles is a serious challenge for orthopedic surgeons, sabotaging the long‐term success of total joint arthroplasty. The existing treatments for aseptic loosening are still far from satisfactory, necessitating more… read more here.

Keywords: titanium particle; emodin; particle induced; induced osteolysis ... See more keywords
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Quercetin alleviates nanoparticle-induced osteolysis via deactivating pyroptosis.

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recommendations! Published in 2023 at "Biomaterials science"

DOI: 10.1039/d3bm00060e

Abstract: As one of the most successful stories in modern medicine, total joint arthroplasty (TJA) is performed several million times worldwide every year. However, more than 20% of patients will suffer from aseptic loosening (AL) following… read more here.

Keywords: nanoparticle induced; alleviates nanoparticle; osteolysis; induced osteolysis ... See more keywords
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Cortistatin attenuates titanium particle-induced osteolysis through regulation of TNFR1-ROS-caspase-3 signaling in osteoblasts.

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recommendations! Published in 2022 at "Annals of the New York Academy of Sciences"

DOI: 10.1111/nyas.14774

Abstract: Aseptic loosening is a major complication of prosthetic joint surgery and is associated with impaired osteoblast homeostasis. Cortistatin (CST) is a neuropeptide that protects against inflammatory conditions. In this study, we found that expression of… read more here.

Keywords: cst; titanium particle; induced osteolysis; particle ... See more keywords
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HUCMSC‐derived Exosomes Suppress the Titanium Particles‐induced Osteolysis in Mice through Inhibiting CCL2 and CCL3

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recommendations! Published in 2023 at "Orthopaedic Surgery"

DOI: 10.1111/os.13608

Abstract: Wear particles induce inflammation and the further osteolysis around the prosthesis, has been proven to be the main cause of aseptic hip joint loosening. In this research, we aimed to clarify whether human umbilical cord… read more here.

Keywords: derived exosomes; osteolysis; induced osteolysis; titanium particles ... See more keywords
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Stevioside Prevents Wear Particle-Induced Osteolysis by Inhibiting Osteoclastogenesis and Inflammatory Response via the Suppression of TAK1 Activation

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recommendations! Published in 2018 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2018.01053

Abstract: Aseptic loosening and periprosthetic osteolysis are the leading causes of total joint arthroplasty failure, which occurs as a result of chronic inflammatory response and enhanced osteoclast activity. Here we showed that stevioside, a natural compound… read more here.

Keywords: particle induced; induced osteolysis; osteolysis; inflammatory response ... See more keywords
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Targeted Delivery of Curcumin to Polyethylene-Induced Osteolysis by Magnetically Guided Zoledronate-Anchored Poly Lactic-Co-Glycolic Acid Nanoparticles via Repressing NF-κB Signaling

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recommendations! Published in 2020 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2020.600156

Abstract: Aseptic loosening induced by periprosthetic osteolysis (PPO) is the leading complication of total joint arthroplasty (TJA) and results in patients having to receive revision surgery. However, there is still no efficient drug to prevent or… read more here.

Keywords: poly lactic; acid nanoparticles; induced osteolysis; osteolysis ... See more keywords
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Phosphatidyl Inositol 3-Kinase (PI3K)-Inhibitor CDZ173 protects against LPS-induced osteolysis

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recommendations! Published in 2023 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2022.1021714

Abstract: A major complication of a joint replacement is prosthesis loosening caused by inflammatory osteolysis, leading to the revision of the operation. This is due to the abnormal activation of osteoclast differentiation and function caused by… read more here.

Keywords: cdz173; osteolysis; pi3k inhibitor; induced osteolysis ... See more keywords
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Lonafarnib Inhibits Farnesyltransferase via Suppressing ERK Signaling Pathway to Prevent Osteoclastogenesis in Titanium Particle-Induced Osteolysis

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recommendations! Published in 2022 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2022.848152

Abstract: Wear debris after total joint arthroplasty can attract the recruitment of macrophages, which release pro-inflammatory substances, triggering the activation of osteoclasts, thereby leading to periprosthetic osteolysis (PPOL) and aseptic loosening. However, the development of pharmacological… read more here.

Keywords: induced osteolysis; osteolysis; titanium particle; particle induced ... See more keywords