Decrease of MiR-31 induced by TNF-α inhibitor activates SATB2/RUNX2 pathway and promotes osteogenic differentiation in ethanol-induced osteonecrosis.
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DOI: 10.1002/jcp.27210
Abstract: PURPOSE Suppressed osteogenic differentiation is considered a main cause of ethanol-induced osteonecrosis. Tumor necrosis factor α (TNF-α) and miR-31 have been reported to be involved in the osteogenic induction. This study aimed to explore a… read more here.
Keywords: tnf inhibitor; differentiation; osteogenic differentiation; ethanol induced ... See more keywords
IL‐4 gene polymorphisms and their relation to steroid‐induced osteonecrosis of the femoral head in Chinese population
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DOI: 10.1002/mgg3.563
Abstract: Steroid‐induced osteonecrosis of the femoral head (ONFH) is a debilitating disease characterized by the activation and infiltration of macrophages into the necrotic site. Interleukin‐4 (IL‐4) administration helped reduce the infiltration of M1 phenotypic macrophages and… read more here.
Keywords: osteonecrosis femoral; femoral head; steroid; steroid induced ... See more keywords
Animal models of steroid-induced osteonecrosis of the femoral head—a comprehensive research review up to 2018
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DOI: 10.1007/s00264-018-3956-1
Abstract: Osteonecrosis of the femoral head (ONFH) is a significant cause of both pain and disability that often affects young adults during what ought to be their most productive age. Two broad categories of ONFH exist:… read more here.
Keywords: osteonecrosis; osteonecrosis femoral; femoral head; steroid induced ... See more keywords
Letter to the editor regarding “Early diagnosis and treatment of steroid-induced osteonecrosis of the femoral head”
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DOI: 10.1007/s00264-019-04402-1
Abstract: To the Editor, It has been a great pleasure to come across the recent article by Weimin Fu et al. [1] in your esteemed journal. I have went through the article with great interest; the… read more here.
Keywords: osteonecrosis femoral; femoral head; editor; early diagnosis ... See more keywords
Bisphosphonate-Induced Osteonecrosis of the Jaws (BIONJ)
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DOI: 10.1007/s12663-019-01211-2
Abstract: Introduction The risk of osteonecrosis of the jaw is greater for patients receiving intravenous bisphosphonates for cancer than for patients receiving oral bisphosphonates for osteoporosis or Paget’s disease. Materials and Methods This article provides a… read more here.
Keywords: osteonecrosis jaws; osteonecrosis; induced osteonecrosis; bisphosphonate induced ... See more keywords
Risk factors and pathogenesis of steroid-induced osteonecrosis of femoral head - A scoping review.
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DOI: 10.1016/j.jcot.2021.101643
Abstract: Steroid induced osteonecrosis of the femoral head is commonly seen in clinical practice, but yet not fully understood. It is intriguing why only some cases develop and others escape from it. We did an extensive… read more here.
Keywords: risk; osteonecrosis femoral; risk factors; steroid induced ... See more keywords
MicroRNA-23b-3p participates in steroid-induced osteonecrosis of the femoral head by suppressing ZNF667 expression
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DOI: 10.1016/j.steroids.2020.108709
Abstract: BACKGROUND Clinical treatment with high-dose of steroid hormone causes steroid-induced osteonecrosis of the femoral head (SONFH), whereas the internal regulation mechanism remains elusive. Numerous studies have reported that microRNAs participated in the development of SONFH… read more here.
Keywords: znf667; mir 23b; steroid induced; expression ... See more keywords
Mechanism of KDM5A‐mediated H3K4me3 modification in the osteogenic differentiation of mesenchymal stem cells in steroid‐induced osteonecrosis of the femoral head
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DOI: 10.1111/1756-185x.15090
Abstract: Steroid‐induced osteonecrosis of the femoral head (SONFH) is characterized by impaired osteogenesis in bone marrow mesenchymal stem cells (BMSCs). This study investigates the role of lysine‐specific demethylase 5A (KDM5A) in SONFH to identify potential therapeutic… read more here.
Keywords: induced osteonecrosis; mesenchymal stem; steroid induced; osteonecrosis femoral ... See more keywords
Icariin promotes angiogenesis in glucocorticoid‐induced osteonecrosis of femoral heads: In vitro and in vivo studies
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DOI: 10.1111/jcmm.14589
Abstract: The injury and dysfunction of the femoral head microvascular endothelial cells are associated with the pathogenesis of glucocorticoid‐induced osteonecrosis of the femoral head (ONFH). Reports indicate that icariin (ICA) can enhance vascular roles and also… read more here.
Keywords: vitro vivo; osteonecrosis femoral; glucocorticoid induced; angiogenesis glucocorticoid ... See more keywords
Noncoding RNAs in Steroid-Induced Osteonecrosis of the Femoral Head
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DOI: 10.1155/2019/8140595
Abstract: Steroid-induced osteonecrosis of the femoral head (ONFH) is a severe orthopedic disease caused by the long-term administration of glucocorticoids. The main pathological feature of ONFH is the gradually progressive necrosis of bone cells and the… read more here.
Keywords: osteonecrosis femoral; femoral head; steroid induced; noncoding rnas ... See more keywords
Inhibition of insulin degrading enzyme suppresses osteoclast hyperactivity via enhancing Nrf2-dependent antioxidant response in glucocorticoid-induced osteonecrosis of the femoral head
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DOI: 10.1186/s10020-024-00880-1
Abstract: Osteoclast hyperactivation due to the pathological overproduction of reactive oxygen species (ROS) stimulated by glucocorticoids (GCs) is one of the key drivers behind glucocorticoid-induced osteonecrosis of the femoral head (GIONFH). The insulin degrading enzyme (IDE),… read more here.
Keywords: induced osteonecrosis; glucocorticoid induced; gionfh; osteonecrosis femoral ... See more keywords