Antiosteoporosis and bone protective effect of nimbolide in steroid‐induced osteoporosis rats
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23209
Abstract: Osteoporosis is a metabolic, hereditary, progressive disease characterized by unusual bone production across the skeleton and a loss the bone tissue microstructure and mass. In this experimental study, we scrutinized the antiosteoporosis effect of nimbolide… read more here.
Keywords: antiosteoporosis bone; osteoporosis rats; induced osteoporosis; effect nimbolide ... See more keywords
ST1926 Attenuates Steroid‐Induced Osteoporosis in Rats by Inhibiting Inflammation Response
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.25812
Abstract: Steroid, also known as glucocorticoid, induced osteonecrosis of the femoral head in young adults, which has been a challenging disorder for the frequent incidence of collapse of femoral head, leading to dysfunction of hip joint… read more here.
Keywords: st1926 treatment; st1926; steroid induced; bone ... See more keywords
Exosomes derived from vascular endothelial cells antagonize glucocorticoid‐induced osteoporosis by inhibiting ferritinophagy with resultant limited ferroptosis of osteoblasts
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30331
Abstract: High dose and long‐term steroid treatment can alter antioxidative ability and decrease the viability and function of osteoblasts, leading to osteoporosis and osteonecrosis. Ferroptosis, a new type of cell death characterized by excessive lipid peroxidation… read more here.
Keywords: glucocorticoid induced; exosomes derived; inhibiting ferritinophagy; ferroptosis ... See more keywords
Glucocorticoid-induced osteoporosis: 2019 concise clinical review
Sign Up to like & getrecommendations! Published in 2019 at "Osteoporosis International"
DOI: 10.1007/s00198-019-04906-x
Abstract: Glucocorticoids remain widely used for many medical conditions, and fractures are the most serious common adverse event related to long-term glucocorticoid use. Glucocorticoid-induced osteoporosis (GIOP) develops in a time- and dose-dependent manner, but even at… read more here.
Keywords: risk; giop; fracture; glucocorticoid induced ... See more keywords
Bone biopsy findings in patients receiving long-term bisphosphonate therapy for glucocorticoid-induced osteoporosis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Metabolism"
DOI: 10.1007/s00774-022-01323-9
Abstract: Bisphosphonates (BPs) have been shown to reduce the incidence of vertebral fractures during the first year or two of glucocorticoid (GC) treatments and are therefore recommended as a first-line treatment for GC-induced osteoporosis (GIO). However,… read more here.
Keywords: giobp group; bone; group; long term ... See more keywords
Renal Osteodystrophy or Kidney-Induced Osteoporosis?
Sign Up to like & getrecommendations! Published in 2017 at "Current Osteoporosis Reports"
DOI: 10.1007/s11914-017-0364-1
Abstract: Purpose of ReviewChronic kidney disease (CKD) affects nearly 10% of the population. The incidence of fractures in population studies demonstrate an increase with worsening stages of kidney disease suggesting specific CKD related causes of fracture.Recent… read more here.
Keywords: bone; induced osteoporosis; ckd; renal osteodystrophy ... See more keywords
Glucocorticoid-induced osteoporosis: an update
Sign Up to like & getrecommendations! Published in 2018 at "Endocrine"
DOI: 10.1007/s12020-018-1588-2
Abstract: Glucocorticoid-induced osteoporosis is the most common secondary cause of osteoporosis and the resulting fractures cause significant morbidity. Following initiation of oral glucocorticoids, rapid bone loss occurs, and fracture risk increases within a few months in… read more here.
Keywords: glucocorticoid induced; glucocorticoid; fracture risk; induced osteoporosis ... See more keywords
Docosahexaenoic Acid-Enriched Phosphatidylcholine Exerted Superior Effects to Triglyceride in Ameliorating Obesity-Induced Osteoporosis through Up-Regulating the Wnt/β-Catenin Pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c06081
Abstract: A growing number of studies reported that obesity is one of the major inducements for osteoporosis by promoting excessive adipogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). Marine-derived DHA-enriched phosphatidylcholine (DHA-PC) exhibited activities to… read more here.
Keywords: obesity induced; enriched phosphatidylcholine; induced osteoporosis; dha ... See more keywords
Pathogenesis of glucocorticoid-induced osteoporosis and options for treatment
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Endocrinology"
DOI: 10.1038/s41574-020-0341-0
Abstract: Glucocorticoids are widely used to suppress inflammation or the immune system. High doses and long-term use of glucocorticoids lead to an important and common iatrogenic complication, glucocorticoid-induced osteoporosis, in a substantial proportion of patients. Glucocorticoids… read more here.
Keywords: long term; glucocorticoid induced; treatment; glucocorticoid ... See more keywords
Extracellular vesicles from endothelial progenitor cells prevent steroid-induced osteoporosis by suppressing the ferroptotic pathway in mouse osteoblasts based on bioinformatics evidence
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-52513-x
Abstract: Abnormal antioxidative capabilities were observed in the pathogenesis of steroid-induced osteoporosis (SIOP). Ferroptosis is a recently discovered type of cell death that is characterized by the overproduction of ROS in response to GPX4 and system… read more here.
Keywords: ferroptotic pathway; epc evs; steroid induced; bone ... See more keywords
Antiresorptive treatments for corticosteroid-induced osteoporosis: a Bayesian network meta-analysis
Sign Up to like & getrecommendations! Published in 2022 at "British Medical Bulletin"
DOI: 10.1093/bmb/ldac017
Abstract: Abstract Introduction Corticosteroid-induced osteoporosis (CIO) is the most common type of secondary osteoporosis, leading to fractures, and increased morbidity and mortality. Source of data Pubmed, EMBASE, Scopus and Google Scholar databases. Areas of agreement Prolonged… read more here.
Keywords: meta analysis; osteoporosis; corticosteroid induced; induced osteoporosis ... See more keywords