Rapid Point-of-Care Genotyping to Avoid Aminoglycoside-Induced Ototoxicity in Neonatal Intensive Care
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Pediatrics"
DOI: 10.1001/jamapediatrics.2022.0187
Abstract: This pragmatic prospective implementation trial uses a rapid genotyping platform for the m.1555A>G variant to assess whether this technology could be implemented to avoid aminoglycoside-induced ototoxicity without disrupting normal clinical practice on neonatal intensive care… read more here.
Keywords: intensive care; neonatal intensive; care; aminoglycoside induced ... See more keywords
Small Extracellular Vesicles Orchestrate Cisplatin‐Induced Ototoxicity: Potential Biomarker and Targets Discovery
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202502627
Abstract: Cisplatin‐induced ototoxicity remains a clinical dilemma with limited mechanistic understanding and no food and drug administration (FDA)‐approved therapies. Despite emerging roles of small extracellular vesicles (sEV) in drug ototoxicity, their molecular cargo profiles and causal… read more here.
Keywords: cisplatin; induced ototoxicity; mmu mir; cis sev ... See more keywords
Aminoglycoside induced ototoxicity risk in the cystic fibrosis population: The utility of large‐scale screening
Sign Up to like & getrecommendations! Published in 2022 at "Pediatric Pulmonology"
DOI: 10.1002/ppul.26259
Abstract: MT‐RNR1 variants are a well‐known cause of aminoglycoside‐induced hearing loss (AIHL). Individuals with cystic fibrosis (CF) routinely receive aminoglycosides and are at high risk of AIHL. However, genetic testing before treatment is not routinely performed… read more here.
Keywords: ototoxicity risk; risk; aminoglycoside induced; cystic fibrosis ... See more keywords
Cisplatin-induced ototoxicity involves interaction of PRMT3 and cannabinoid system
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Toxicology"
DOI: 10.1007/s00204-019-02507-5
Abstract: This study investigated whether protein arginine methyltransferase (PRMT) and the cannabinoid system are involved in cisplatin-induced ototoxicity. Cisplatin increased cytosine–cytosine–adenosine–adenosine–thymidine–enhancer-binding protein homologous protein expression. This effect is indicative of an increase in endoplasmic reticulum (ER)… read more here.
Keywords: cisplatin; induced ototoxicity; cannabinoid; cisplatin induced ... See more keywords
The protective role of tetramethylpyrazine against cisplatin-induced ototoxicity.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pediatric otorhinolaryngology"
DOI: 10.1016/j.ijporl.2017.01.005
Abstract: OBJECTIVES The aim of the present study was to investigate the protective effect of tetramethylpyrazine (TMP) on cisplatin-induced ototoxicity in rats. METHODS Forty healthy, female, 24-week-old, Sprague-Dawley rats (n = 40) were randomly assigned to four groups… read more here.
Keywords: cisplatin; group; induced ototoxicity; ototoxicity ... See more keywords
Protective roles of fenofibrate against cisplatin‐induced ototoxicity by the rescue of peroxisomal and mitochondrial dysfunction
Sign Up to like & getrecommendations! Published in 2018 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2018.06.010
Abstract: &NA; Cisplatin is an alkylating agent that interferes with DNA replication and kills proliferating carcinogenic cells. Several studies have been conducted to attenuate the side effects of cisplatin; one such side effect in cancer patients… read more here.
Keywords: cisplatin; induced ototoxicity; cisplatin induced; fenofibrate ... See more keywords
Tauroursodeoxycholic acid attenuates cisplatin-induced ototoxicity by inhibiting the accumulation and aggregation of unfolded or misfolded proteins in the endoplasmic reticulum.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology"
DOI: 10.1016/j.tox.2021.152736
Abstract: Cisplatin-induced ototoxicity is one of the important reasons that limit the drug's clinical application, and its mechanism has not been fully elucidated so far. The aim of this study was to explore the attenuate effect… read more here.
Keywords: aggregation; tudca; cisplatin; induced ototoxicity ... See more keywords
The Effects of Riluzole on Cisplatin-induced Ototoxicity
Sign Up to like & getrecommendations! Published in 2019 at "International Archives of Otorhinolaryngology"
DOI: 10.1055/s-0038-1676654
Abstract: Introduction Riluzole (2-amino-6-trifluoromethoxy benzothiazole) is known as a neuroprotective, antioxidant, antiapoptotic agent. It may have beneficial effects on neuronal cell death due to cisplatin-induced ototoxicity. Objective To evaluate the effect of riluzole on cisplatin-induced ototoxicity… read more here.
Keywords: microscopy; cisplatin; induced ototoxicity; cisplatin induced ... See more keywords
The PERK/ATF4/CHOP signaling branch of the unfolded protein response mediates cisplatin-induced ototoxicity in hair cells
Sign Up to like & getrecommendations! Published in 2022 at "Drug and Chemical Toxicology"
DOI: 10.1080/01480545.2022.2039181
Abstract: Abstract Cisplatin is a widely used chemotherapeutic agent. However, its clinical application remains limited due to the high incidence of severe ototoxicity. It has been reported that the unfolded protein response (UPR) is involved in… read more here.
Keywords: chop; hair; cisplatin induced; cisplatin ... See more keywords
Ezetimibe protects against Gentamycin-induced ototoxicity in rats by antioxidants, anti-inflammatory mechanisms, and BDNF upregulation
Sign Up to like & getrecommendations! Published in 2024 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2024.2390463
Abstract: Abstract Objective The threat of hearing loss has become a universal reality. Gentamycin (GM) can lead to ototoxicity and may result in permanent hearing loss. This study aimed to elucidate whether the hypolipidemic drug Ezetimibe… read more here.
Keywords: immunoreaction; ototoxicity; gentamycin; ezetimibe ... See more keywords
Ameliorative effect of taxifolin on gentamicin-induced ototoxicity via down-regulation of apoptotic pathways in mouse cochlear UB/OC-2 cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the Chinese Medical Association"
DOI: 10.1097/jcma.0000000000000708
Abstract: Background: Taxifolin is a flavanonol with efficacious cytoprotective properties, such as anti-inflammatory, antioxidant, anticancer, hepatoprotective, and nephroprotective effects. However, the potential protective effects of taxifolin against gentamicin-induced ototoxicity have not been confirmed. In this study,… read more here.
Keywords: gentamicin induced; taxifolin gentamicin; taxifolin; cochlear cells ... See more keywords