Tri-ortho-cresyl phosphate (TOCP) induced ovarian failure in mice is related to the Hippo signaling pathway disruption.
Sign Up to like & getrecommendations! Published in 2019 at "Reproductive toxicology"
DOI: 10.1016/j.reprotox.2018.10.007
Abstract: As a plasticizer widely used in society, tri-ortho-cresyl phosphate (TOCP) is reported to inhibit spermatogenesis and growth of spermatogonial stem cells. However, its effects on female reproductive system are virtually unknown. The present study investigated… read more here.
Keywords: ortho cresyl; induced ovarian; tri ortho; tocp induced ... See more keywords
Ameliorative effect of gallic acid on cisplatin-induced ovarian toxicity in rats.
Sign Up to like & getrecommendations! Published in 2021 at "Drug and chemical toxicology"
DOI: 10.1080/01480545.2021.2011312
Abstract: The aim of the present study was to evaluate the protective effect of gallic acid (GA) against cisplatin (CDDP)-induced ovarian toxicity, for the first time. The ovarian damage was generated with CDDP (5 mg/kg) intraperitoneally (i.p.)… read more here.
Keywords: gallic acid; group; cddp; effect gallic ... See more keywords
MicroRNA-146 attenuates lipopolysaccharide induced ovarian dysfunction by inhibiting the TLR4/NF- κB signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2070584
Abstract: ABSTRACT Premature ovarian insufficiency (POI) is a disease that seriously affects women’s reproductive function and even leads to lifelong infertility. Little is known about the mechanism of lipopolysaccharide (LPS)-induced ovarian dysfunction. Thus, we aimed to… read more here.
Keywords: signaling pathway; dysfunction inhibiting; dysfunction; induced ovarian ... See more keywords
Protective Effects of Antioxidants on Cyclophosphamide-Induced Ovarian Toxicity.
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DOI: 10.1089/bio.2021.0159
Abstract: The most common limitation of anticancer chemotherapy is the injury to normal cells. Cyclophosphamide, which is one of the most widely used alkylating agents, can cause premature ovarian insufficiency and infertility since the ovarian follicles… read more here.
Keywords: protective effects; effects antioxidants; toxicity; antioxidants cyclophosphamide ... See more keywords
Senotherapy Protects against Cisplatin-Induced Ovarian Injury by Removing Senescent Cells and Alleviating DNA Damage
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/9144644
Abstract: Ovarian damage induced by platinum-based chemotherapy seriously affects young women with cancer, manifesting as infertility, early menopause, and premature ovarian insufficiency. However, effective prevention strategies for such damage are lacking. Senescent cells may be induced… read more here.
Keywords: damage; dna damage; senescent cells; cisplatin induced ... See more keywords
Amburana cearensis leaf extract protects against cisplatin-induced ovarian damage through regulation of p-PTEN and p-Akt proteins in mice
Sign Up to like & getrecommendations! Published in 2022 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2022.58927.13092
Abstract: Objective(s): To evaluate the effects of Amburana cearensis leaf extract against cisplatin-induced ovarian toxicity in mice and involvement of p-PTEN and p-Akt proteins. Materials and Methods: A. cearensis ethanolic leaf extract was analyzed by high-performance… read more here.
Keywords: pten akt; extract; cearensis; induced ovarian ... See more keywords
Analysis of circRNA and miRNA expression profiles in IGF3-induced ovarian maturation in spotted scat (Scatophagus argus)
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DOI: 10.3389/fendo.2022.998207
Abstract: Insulin-like growth factor 3 (IGF3) induces ovarian maturation in teleosts; however, research on its molecular regulatory mechanism remains deficient. Circular RNAs (circRNAs) and microRNAs (miRNAs) are involved in various biological processes, including reproduction. In this… read more here.
Keywords: maturation; signaling pathway; ovarian maturation; igf3 induced ... See more keywords
Folic Acid Preconditioning Alleviated Radiation-Induced Ovarian Dysfunction in Female Mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Nutrition"
DOI: 10.3389/fnut.2022.854655
Abstract: Radiological therapy/examination is the primary source of artificial radiation exposure in humans. While its application has contributed to major advances in disease diagnosis and treatment, ionizing radiation exposure is associated with ovarian damage. The use… read more here.
Keywords: radiation induced; folic acid; radiation; mice ... See more keywords
Empagliflozin Protects against Haloperidol Experimentally-Induced Ovarian Toxicity
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DOI: 10.3390/ph16020168
Abstract: The present experiment aimed to identify the potential protective role of empagliflozin (EMPA) on haloperidol (HAL)-induced ovarian damage in female rats because of its anti-inflammatory, antioxidant, and antiapoptotic effects. EMPA was administered in the presence… read more here.
Keywords: inflammatory apoptotic; oxidative stress; ovarian toxicity; group ... See more keywords