Hesperidin Attenuates Acrylamide-Induced Ovarian Toxicity in Rats: Based on Network Pharmacology, Molecular Docking, and In Vivo Studies.
Sign Up to like & getrecommendations! Published in 2025 at "Environmental toxicology"
DOI: 10.1002/tox.24577
Abstract: Exposure to acrylamide (AA) through food is nearly unavoidable and can lead to long-lasting consequences. AA has been shown to cause reproductive toxicity and reduce ovarian weight and follicle number when taken orally. Flavonoids derived… read more here.
Keywords: molecular docking; induced ovarian; attenuates acrylamide; pharmacology ... See more keywords
Tri-ortho-cresyl phosphate (TOCP) induced ovarian failure in mice is related to the Hippo signaling pathway disruption.
Sign Up to like & getrecommendations! Published in 2019 at "Reproductive toxicology"
DOI: 10.1016/j.reprotox.2018.10.007
Abstract: As a plasticizer widely used in society, tri-ortho-cresyl phosphate (TOCP) is reported to inhibit spermatogenesis and growth of spermatogonial stem cells. However, its effects on female reproductive system are virtually unknown. The present study investigated… read more here.
Keywords: ortho cresyl; induced ovarian; tri ortho; tocp induced ... See more keywords
Ameliorative effect of gallic acid on cisplatin-induced ovarian toxicity in rats.
Sign Up to like & getrecommendations! Published in 2021 at "Drug and chemical toxicology"
DOI: 10.1080/01480545.2021.2011312
Abstract: The aim of the present study was to evaluate the protective effect of gallic acid (GA) against cisplatin (CDDP)-induced ovarian toxicity, for the first time. The ovarian damage was generated with CDDP (5 mg/kg) intraperitoneally (i.p.)… read more here.
Keywords: gallic acid; group; cddp; effect gallic ... See more keywords
Febuxostat attenuates cyclophosphamide-induced ovarian toxicity; role of TLR4/NFκB/NLRP3 signaling pathway in female wistar albino rats
Sign Up to like & getrecommendations! Published in 2025 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2025.2583496
Abstract: Abstract Background Our goal was to assess if febuxostat (FEB) could prevent ovarian damage caused by cyclophosphamide (CP). Material and methods Four sets were created: control group, FEB group: received FEB 10 mg/kg orally for 14 days,… read more here.
Keywords: induced ovarian; ovarian toxicity; expression; signaling pathway ... See more keywords
MicroRNA-146 attenuates lipopolysaccharide induced ovarian dysfunction by inhibiting the TLR4/NF- κB signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2070584
Abstract: ABSTRACT Premature ovarian insufficiency (POI) is a disease that seriously affects women’s reproductive function and even leads to lifelong infertility. Little is known about the mechanism of lipopolysaccharide (LPS)-induced ovarian dysfunction. Thus, we aimed to… read more here.
Keywords: signaling pathway; dysfunction inhibiting; dysfunction; induced ovarian ... See more keywords
Protective Effects of Antioxidants on Cyclophosphamide-Induced Ovarian Toxicity.
Sign Up to like & getrecommendations! Published in 2022 at "Biopreservation and biobanking"
DOI: 10.1089/bio.2021.0159
Abstract: The most common limitation of anticancer chemotherapy is the injury to normal cells. Cyclophosphamide, which is one of the most widely used alkylating agents, can cause premature ovarian insufficiency and infertility since the ovarian follicles… read more here.
Keywords: protective effects; effects antioxidants; toxicity; antioxidants cyclophosphamide ... See more keywords
The Protective Effect of Gallic Acid Against Bisphenol A-Induced Ovarian Toxicity and Endocrine Disruption in Female Rats
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DOI: 10.1089/jmf.2024.0088
Abstract: Purpose: This study aimed to investigate the protective effects of gallic acid (GA) against ovarian damage induced by bisphenol A (BPA) exposure in female rats. We evaluated whether GA can mitigate the adverse effects of… read more here.
Keywords: female rats; induced ovarian; gallic acid; damage ... See more keywords
Protective effects of Azilsartan against cyclophosphamide-induced ovarian toxicity in rats model.
Sign Up to like & getrecommendations! Published in 2024 at "Toxicology research"
DOI: 10.1093/toxres/tfae027
Abstract: Background Cyclophosphamide (CP) is an effective alkylating anticancer agent that is widely used in cancer chemotherapy, and it can cause ototoxicity and infertility in women. Objectives So, this study aimed to evaluate the protective effects… read more here.
Keywords: protective effects; induced ovarian; compared control; ovarian toxicity ... See more keywords
Senotherapy Protects against Cisplatin-Induced Ovarian Injury by Removing Senescent Cells and Alleviating DNA Damage
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DOI: 10.1155/2022/9144644
Abstract: Ovarian damage induced by platinum-based chemotherapy seriously affects young women with cancer, manifesting as infertility, early menopause, and premature ovarian insufficiency. However, effective prevention strategies for such damage are lacking. Senescent cells may be induced… read more here.
Keywords: damage; dna damage; senescent cells; cisplatin induced ... See more keywords
Influence of Ascorbic Acid on Di-(2-Ethylhexyl) Phthalate-induced Ovarian Gene Alterations in Pubertal Female Wistar Rats
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Pharmacology and Pharmacotherapeutics"
DOI: 10.1177/0976500x241245481
Abstract: Background Di-(2-ethylhexyl) phthalate (DEHP), a plasticizer compound affecting female reproduction, leads to scenarios, such as polycystic ovarian syndrome (PCOS) and infertility through oxidative stress (OS) mechanisms. Ascorbic acid (AA) is one of the antioxidants in… read more here.
Keywords: female wistar; wistar rats; induced ovarian; group ... See more keywords
Phenolic-loaded nanofiber from Arctium lappa root: a potential therapy for testosterone-induced ovarian oxidative stress
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Biological Engineering"
DOI: 10.1186/s13036-025-00515-x
Abstract: Polycystic Ovary Syndrome (PCOS) is a hormonal disorder affecting women of reproductive age, often associated with oxidative stress and inflammation. This study explores the therapeutic potential of Arctium lappa phenolic-rich fraction encapsulated nanofiber (ALPRF-NF) in… read more here.
Keywords: arctium lappa; oxidative stress; induced ovarian; testosterone induced ... See more keywords