Aspirin eugenol ester inhibits agonist‐induced platelet aggregation in vitro by regulating PI3K/Akt, MAPK and Sirt 1/CD40L pathways
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2019.02.032
Abstract: ABSTRACT Aspirin eugenol ester (AEE) was a promising drug candidate for treating inflammation, pain and fever and preventing cardiovascular diseases with fewer side effects than its precursors. Previous researches indicated that AEE could markedly inhibit… read more here.
Keywords: platelet aggregation; induced platelet; agonist induced; aggregation vitro ... See more keywords
Shear-induced platelet aggregation: 3D-grayscale microfluidics for repeatable and localized occlusive thrombosis.
Sign Up to like & getrecommendations! Published in 2019 at "Biomicrofluidics"
DOI: 10.1063/1.5113508
Abstract: Atherothrombosis leads to complications of myocardial infarction and stroke as a result of shear-induced platelet aggregation (SIPA). Clinicians and researchers may benefit from diagnostic and benchtop microfluidic assays that assess the thrombotic activity of an… read more here.
Keywords: platelet aggregation; induced platelet; shear induced; thrombosis ... See more keywords
Inhibition of agonist-induced platelet aggregation by magnesium sulfate warrants its use as an alternative in vitro anticoagulant in pseudothrombocytopenia
Sign Up to like & getrecommendations! Published in 2019 at "Platelets"
DOI: 10.1080/09537104.2019.1663804
Abstract: Abstract MgSO4 is effective in preventing spontaneous in vitro platelet agglutination in anticoagulant-induced pseudothrombocytopenia (PTCP). In order to learn more about its potential as an in vitro anticoagulant, platelets from MgSO4-anticoagulated blood were stimulated by… read more here.
Keywords: induced platelet; aggregation; vitro anticoagulant; platelet aggregation ... See more keywords
Reduction of ristocetin-induced platelet aggregation (RIPA) during storage despite plasma renewal: evidence for hemostatic importance of GPIbα shedding
Sign Up to like & getrecommendations! Published in 2024 at "Expert Review of Hematology"
DOI: 10.1080/17474086.2024.2370557
Abstract: ABSTRACT Background Platelet storage is complicated by deleterious changes, among which reduction of ristocetin-induced platelet aggregation (RIPA) has a poorly understood mechanism. The study elucidates the mechanistic roles of all the possible players in this… read more here.
Keywords: platelet aggregation; induced platelet; ripa; reduction ... See more keywords
ADP-induced platelet aggregation in patients with acute coronary syndrome treated with prasugrel or ticagrelor. Results of the ISAR REACT 5 platelet aggregation substudy
Sign Up to like & getrecommendations! Published in 2020 at "European Heart Journal"
DOI: 10.1093/ehjci/ehaa946.1721
Abstract: The recently published randomized multicenter open label ISAR REACT 5 trial showed that prasugrel was superior to ticagrelor with respect to the composite primary end point of death, myocardial infarction, or stroke at one year… read more here.
Keywords: induced platelet; aggregation; ticagrelor; adp induced ... See more keywords
Novel Antiplatelet Activity of Ginsenoside Re through the Inhibition of High Shear Stress-Induced Platelet Aggregation.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cardiovascular pharmacology"
DOI: 10.1097/fjc.0000000000001417
Abstract: ABSTRACT Bleeding is one of the most serious side effects of antiplatelet drugs. Efforts have been made to find new antiplatelet agents without bleeding complications. Shear-induced platelet aggregation (SIPA) occurs only under pathological conditions and… read more here.
Keywords: platelet; shear stress; induced platelet; platelet aggregation ... See more keywords
Linking Computational Fluid Dynamics Modeling to Device-Induced Platelet Defects in Mechanically Assisted Circulation
Sign Up to like & getrecommendations! Published in 2024 at "ASAIO Journal"
DOI: 10.1097/mat.0000000000002242
Abstract: Thrombotic and bleeding events are the most common hematologic complications in patients with mechanically assisted circulation and are closely related to device-induced platelet dysfunction. In this study, we sought to link computational fluid dynamics (CFD)… read more here.
Keywords: induced platelet; mechanically assisted; device induced; platelet ... See more keywords
Antithrombotic effect of SP‐8008, a benzoic acid derivative, through the selective inhibition of shear stress‐induced platelet aggregation
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14894
Abstract: Bleeding is one of the most critical adverse effects of antithrombotic drugs, and many efforts have been made to discover novel antiplatelet agents without bleeding complications. Shear stress‐induced platelet aggregation (SIPA), where the interaction of… read more here.
Keywords: induced platelet; shear stress; platelet aggregation; stress induced ... See more keywords
PF4‐dependent P‐selectin expression assay in comparison to the heparin‐induced platelet activation assay for the diagnosis of heparin‐induced thrombocytopenia
Sign Up to like & getrecommendations! Published in 2025 at "Transfusion"
DOI: 10.1111/trf.18242
Abstract: Heparin‐induced thrombocytopenia (HIT) is a severe complication characterized by thrombocytopenia and thrombosis. The presence of antibodies against heparin/platelet factor 4 (PF4) complexes is a key indicator for HIT. Diagnostic laboratory testing generally includes detection of… read more here.
Keywords: heparin; induced platelet; induced thrombocytopenia; platelet activation ... See more keywords
Models of Shear-Induced Platelet Activation and Numerical Implementation with Computational Fluid Dynamics Approaches.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of biomechanical engineering"
DOI: 10.1115/1.4052460
Abstract: Shear-induced platelet activation is one of the critical outcomes when blood is exposed to elevated shear stress. Excessively activated platelets in the circulation can lead to thrombus formation and platelet consumption, resulting in serious adverse… read more here.
Keywords: induced platelet; shear induced; shear stress; platelet activation ... See more keywords
Retracted: Effect of Evodiamine on Collagen-Induced Platelet Activation and Thrombosis
Sign Up to like & getrecommendations! Published in 2024 at "BioMed Research International"
DOI: 10.1155/2024/9850671
Abstract: [This retracts the article DOI: 10.1155/2022/4893859.]. read more here.
Keywords: evodiamine collagen; induced platelet; retracted effect; platelet activation ... See more keywords