Aspirin eugenol ester inhibits agonist‐induced platelet aggregation in vitro by regulating PI3K/Akt, MAPK and Sirt 1/CD40L pathways
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2019.02.032
Abstract: ABSTRACT Aspirin eugenol ester (AEE) was a promising drug candidate for treating inflammation, pain and fever and preventing cardiovascular diseases with fewer side effects than its precursors. Previous researches indicated that AEE could markedly inhibit… read more here.
Keywords: platelet aggregation; induced platelet; agonist induced; aggregation vitro ... See more keywords
Shear-induced platelet aggregation: 3D-grayscale microfluidics for repeatable and localized occlusive thrombosis.
Sign Up to like & getrecommendations! Published in 2019 at "Biomicrofluidics"
DOI: 10.1063/1.5113508
Abstract: Atherothrombosis leads to complications of myocardial infarction and stroke as a result of shear-induced platelet aggregation (SIPA). Clinicians and researchers may benefit from diagnostic and benchtop microfluidic assays that assess the thrombotic activity of an… read more here.
Keywords: platelet aggregation; induced platelet; shear induced; thrombosis ... See more keywords
Inhibition of agonist-induced platelet aggregation by magnesium sulfate warrants its use as an alternative in vitro anticoagulant in pseudothrombocytopenia
Sign Up to like & getrecommendations! Published in 2019 at "Platelets"
DOI: 10.1080/09537104.2019.1663804
Abstract: Abstract MgSO4 is effective in preventing spontaneous in vitro platelet agglutination in anticoagulant-induced pseudothrombocytopenia (PTCP). In order to learn more about its potential as an in vitro anticoagulant, platelets from MgSO4-anticoagulated blood were stimulated by… read more here.
Keywords: induced platelet; aggregation; vitro anticoagulant; platelet aggregation ... See more keywords
ADP-induced platelet aggregation in patients with acute coronary syndrome treated with prasugrel or ticagrelor. Results of the ISAR REACT 5 platelet aggregation substudy
Sign Up to like & getrecommendations! Published in 2020 at "European Heart Journal"
DOI: 10.1093/ehjci/ehaa946.1721
Abstract: The recently published randomized multicenter open label ISAR REACT 5 trial showed that prasugrel was superior to ticagrelor with respect to the composite primary end point of death, myocardial infarction, or stroke at one year… read more here.
Keywords: induced platelet; aggregation; ticagrelor; adp induced ... See more keywords
Novel Antiplatelet Activity of Ginsenoside Re through the Inhibition of High Shear Stress-Induced Platelet Aggregation.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cardiovascular pharmacology"
DOI: 10.1097/fjc.0000000000001417
Abstract: ABSTRACT Bleeding is one of the most serious side effects of antiplatelet drugs. Efforts have been made to find new antiplatelet agents without bleeding complications. Shear-induced platelet aggregation (SIPA) occurs only under pathological conditions and… read more here.
Keywords: platelet; shear stress; induced platelet; platelet aggregation ... See more keywords
Antithrombotic effect of SP‐8008, a benzoic acid derivative, through the selective inhibition of shear stress‐induced platelet aggregation
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14894
Abstract: Bleeding is one of the most critical adverse effects of antithrombotic drugs, and many efforts have been made to discover novel antiplatelet agents without bleeding complications. Shear stress‐induced platelet aggregation (SIPA), where the interaction of… read more here.
Keywords: induced platelet; shear stress; platelet aggregation; stress induced ... See more keywords
Models of Shear-Induced Platelet Activation and Numerical Implementation with Computational Fluid Dynamics Approaches.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of biomechanical engineering"
DOI: 10.1115/1.4052460
Abstract: Shear-induced platelet activation is one of the critical outcomes when blood is exposed to elevated shear stress. Excessively activated platelets in the circulation can lead to thrombus formation and platelet consumption, resulting in serious adverse… read more here.
Keywords: induced platelet; shear induced; shear stress; platelet activation ... See more keywords
Investigation of shear-induced platelet activation in ventricular assist device
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science"
DOI: 10.1177/09544062221124012
Abstract: Due to the scarcity of organ donations, ventricular assist devices are the most accessible treatment for patients with advanced heart failure. Since their development, these devices have helped thousands of patients and could have helped… read more here.
Keywords: platelet activation; induced platelet; ventricular assist; blade ... See more keywords
Hyperglycemia enhances arsenic-induced platelet and megakaryocyte activation
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-017-1148-1
Abstract: ObjectiveLow to moderate inorganic arsenic (iAs) exposure is independently associated with cardiovascular disease (CVD), particularly for patients with diabetes mellitus (DM). The mechanism of increased CVD risk from iAs exposure in DM has not been… read more here.
Keywords: induced platelet; incubation; platelet megakaryocyte; activation ... See more keywords
Perspective: Collagen induced platelet activation via the GPVI receptor as a primary target of colchicine in cardiovascular disease
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.1104744
Abstract: Colchicine has been demonstrated to reduce cardiovascular death, myocardial infarction (MI), ischemic stroke, and ischemia-driven coronary revascularization in people with coronary artery disease (CAD). These reductions were observed even in patients already taking antiplatelet therapy.… read more here.
Keywords: gpvi; collagen induced; platelet activation; induced platelet ... See more keywords
Complement C3b contributes to Escherichia coli-induced platelet aggregation in human whole blood
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1020712
Abstract: Introduction Platelets have essential functions as first responders in the immune response to pathogens. Activation and aggregation of platelets in bacterial infections can lead to life-threatening conditions such as arterial thromboembolism or sepsis-associated coagulopathy. Methods… read more here.
Keywords: aggregation; induced platelet; platelet aggregation; whole blood ... See more keywords