Engineering of Mature Human Induced Pluripotent Stem Cell‐Derived Cardiomyocytes Using Substrates with Multiscale Topography
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DOI: 10.1002/adfm.201707378
Abstract: Producing mature and functional cardiomyocytes (CMs) by in vitro differentiation of induced pluripotent stem cells (iPSCs) using only biochemical cues is challenging. To mimic the biophysical and biomechanical complexity of the native in vivo environment… read more here.
Keywords: topography; mature; pluripotent stem; induced pluripotent ... See more keywords
Thermoresponsive Hydrogels as Microniches for Growth and Controlled Release of Induced Pluripotent Stem Cells
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DOI: 10.1002/adfm.202010630
Abstract: The recently emerging stem‐cell artificial niche engineering in induced pluripotent stem cell (iPSCs) 3D cultures has provided enormous opportunities to fully utilize the potential of these cells in biomedical applications. Although a fully chemically defined… read more here.
Keywords: controlled release; niche; induced pluripotent; pluripotent stem ... See more keywords
Large‐Scale Production of Wholly Cellular Bioinks via the Optimization of Human Induced Pluripotent Stem Cell Aggregate Culture in Automated Bioreactors
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202201138
Abstract: Combining the sustainable culture of billions of human cells and the bioprinting of wholly cellular bioinks offers a pathway toward organ‐scale tissue engineering. Traditional 2D culture methods are not inherently scalable due to cost, space,… read more here.
Keywords: culture; cell; induced pluripotent; wholly cellular ... See more keywords
Optimized protocol for the hepatic differentiation of induced pluripotent stem cells in a fluidic microenvironment
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26970
Abstract: In the present study, we evaluated the performance of different protocols for the hepatic differentiation of human‐induced pluripotent stem cells (hiPSCs) in microfluidic biochips. Strategies for complete and partial on‐chip differentiation were tested. Unlike full… read more here.
Keywords: hepatic differentiation; differentiation; pluripotent stem; induced pluripotent ... See more keywords
Micropatterned substrates with physiological stiffness promote cell maturation and Pompe disease phenotype in human induced pluripotent stem cell‐derived skeletal myocytes
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.27075
Abstract: Recent advances in bioengineering have enabled cell culture systems that more closely mimic the native cellular environment. Here, we demonstrated that human induced pluripotent stem cell (iPSC)‐derived myogenic progenitors formed highly‐aligned myotubes and contracted when… read more here.
Keywords: human induced; disease; stem cell; pluripotent stem ... See more keywords
Diphenyleneiodonium efficiently inhibits the characteristics of a cancer stem cell model derived from induced pluripotent stem cells
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3696
Abstract: Diphenyleneiodonium (DPI) has long been evaluated as an anticancer drug inhibiting NADPH oxidase, the IC50 in several cancer cell lines was reported 10 µM, which is too high for efficacy. In this study, we employed miPS‐Huh7cmP… read more here.
Keywords: stem cell; pluripotent stem; cancer stem; induced pluripotent ... See more keywords
Quantitative Assessment of Sialo‐Glycoproteins and N‐Glycans during Cardiomyogenic Differentiation of Human Induced Pluripotent Stem Cells
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DOI: 10.1002/cbic.201700100
Abstract: Human induced pluripotent stem‐cell‐derived cardiomyocytes (hiPSC CMs) may be used in regenerative medicine for individualized tissue transplants in the future. For application in patients, the generated CMs have to be highly pure and well characterized.… read more here.
Keywords: glycoproteins glycans; sialo glycoproteins; human induced; differentiation ... See more keywords
Transnasal transplantation of human induced pluripotent stem cell‐derived microglia to the brain of immunocompetent mice
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DOI: 10.1002/glia.23985
Abstract: Microglia are the resident immune cells of the brain, and play essential roles in neuronal development, homeostatic function, and neurodegenerative disease. Human microglia are relatively different from mouse microglia. However, most research on human microglia… read more here.
Keywords: cell derived; human microglia; stem cell; induced pluripotent ... See more keywords
Connexin43 Mutant Patient‐Derived Induced Pluripotent Stem Cells Exhibit Altered Differentiation Potential
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DOI: 10.1002/jbmr.3098
Abstract: We present for the first time the generation of induced pluripotent stem cells (iPSCs) from a patient with a connexin‐linked disease. The importance of gap junctional intercellular communication in bone homeostasis is exemplified by the… read more here.
Keywords: oddd ipscs; differentiation; pluripotent stem; induced pluripotent ... See more keywords
Differentiation of Induced Pluripotent Stem Cells Into Chondrocytes: Methods and Applications for Disease Modeling and Drug Discovery
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DOI: 10.1002/jbmr.4524
Abstract: Induced pluripotent stem cell (iPSC) technology allows pathomechanistic and therapeutic investigation of human heritable disorders affecting tissue types whose collection from patients is difficult or even impossible. Among them are cartilage diseases. Over the past… read more here.
Keywords: pluripotent stem; disease; induced pluripotent; differentiation induced ... See more keywords
Small‐molecule–based generation of functional cardiomyocytes from human umbilical cord–derived induced pluripotent stem cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27094
Abstract: The purpose of this study was to investigate the cardiac‐differentiation potential of induced pluripotent stem cells (iPSCs) generated from human umbilical cord–derived mesenchymal cells. Spontaneous beating colonies were observed at day 7 after the sequential… read more here.
Keywords: umbilical cord; cord derived; functional cardiomyocytes; human umbilical ... See more keywords