Cyclin-dependent kinase 5 contributes to endoplasmic reticulum stress induced podocyte apoptosis via promoting MEKK1 phosphorylation at Ser280 in diabetic nephropathy.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2016.12.009
Abstract: Endoplasmic reticulum (ER) stress has been reported to be associated with podocyte apoptosis in diabetic nephropathy, but the mechanism of ER signaling in podocyte apoptosis hasn't been fully understood. Our previous studies have demonstrated that… read more here.
Keywords: podocyte apoptosis; apoptosis; stress induced; diabetic nephropathy ... See more keywords
Bousigonine A and B, bis- and tri-indole alkaloids from Bousigonia mekongensis and their preventing high glucose-induced podocyte injury activity
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DOI: 10.1016/j.tetlet.2019.151042
Abstract: Abstract Bousigonine A (1), an unprecedented eburnamine-voaphylline type dimeric indole alkaloid, and Bousigonine B (2), the first example of eburnamine-eburnamine-aspidospermine type trimeric indole alkaloid were isolated from Bousigonia mekongensis. Their structures were elucidated mainly by… read more here.
Keywords: bousigonia mekongensis; induced podocyte; preventing high; glucose induced ... See more keywords
MiR-130a-5p prevents angiotensin II-induced podocyte apoptosis by modulating M-type phospholipase A2 receptor
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DOI: 10.1080/15384101.2018.1542901
Abstract: ABSTRACT Podocyte apoptosis is considered as the important element that promotes the development and progress of membranous nephropathy (MN). Unfortunately, the underlying mechanism of podocytes apoptosis in MN remains elusive. We compared the renal expressions… read more here.
Keywords: podocyte apoptosis; apoptosis; phospholipase receptor; type phospholipase ... See more keywords
Metformin prevents hypoxia‐induced podocyte injury by regulating the ZEB2/TG2 axis
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DOI: 10.1111/nep.14121
Abstract: Podocytes, a vital component of the glomerular filtration barrier, are vulnerable to various noxious stimuli, including Hypoxic. HIF1α that transduces hypoxic adaptations induces Transglutaminase 2 (TG2), which catalyses cross‐linking of extracellular matrix proteins. In this… read more here.
Keywords: hypoxia induced; metformin prevents; induced podocyte; podocyte injury ... See more keywords
FTY720 Attenuates Angiotensin II-Induced Podocyte Damage via Inhibiting Inflammatory Cytokines
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DOI: 10.1155/2017/3701385
Abstract: FTY720, a new chemical substance derived from the ascomycete Isaria sinclairii, is used for treating multiple sclerosis, renal cancer, and asthma. Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid metabolite and exists in red blood cells.… read more here.
Keywords: inflammatory cytokines; damage; s1p; induced podocyte ... See more keywords
Tangshenning Attenuates High Glucose-Induced Podocyte Injury via Restoring Autophagy Activity through Inhibiting mTORC1 Activation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Diabetes Research"
DOI: 10.1155/2022/1610416
Abstract: Diabetic nephropathy (DN) is a microvascular complication of diabetes mellitus (DM) and the most common cause of death in diabetic patients. DN progression is associated with podocyte damage due to reduced autophagy caused by mTORC1… read more here.
Keywords: glucose induced; induced podocyte; podocyte injury; high glucose ... See more keywords
Cyr61 Mediates Angiotensin II-Induced Podocyte Apoptosis via the Upregulation of TXNIP
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DOI: 10.1155/2023/8643548
Abstract: Purpose It is well documented that angiotensin II (Ang II) elevation promotes apoptosis of podocytes in vivo and vitro, but the potential mechanism is still oscular. The current study is aimed at probing into the… read more here.
Keywords: cyr61; induced podocyte; expression; ang ... See more keywords
Epidermal Growth Factor Protects Against High Glucose-Induced Podocyte Injury Possibly via Modulation of Autophagy and PI3K/AKT/mTOR Signaling Pathway Through DNA Methylation
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DOI: 10.2147/dmso.s299562
Abstract: Aim Diabetic nephropathy (DN) is a serious health problem worldwide. Epidermal growth factor (EGF) has suggested as a potential biomarker for the progression of chronic kidney disease. In this study, we examined the effects of… read more here.
Keywords: methylation; dna methylation; cell; podocyte injury ... See more keywords
Morroniside Inhibits H2O2-Induced Podocyte Apoptosis by Down-Regulating NOX4 Expression Controlled by Autophagy In Vitro
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DOI: 10.3389/fphar.2020.533809
Abstract: Podocyte apoptosis is the common pathological basis for the progression of various kidney diseases. The overexpression of NOX4, a key enzyme involved in oxidative stress, has been proved to participate in the occurrence of podocyte… read more here.
Keywords: podocyte apoptosis; apoptosis; morroniside; nox4 expression ... See more keywords
Fisetin Attenuates Diabetic Nephropathy-Induced Podocyte Injury by Inhibiting NLRP3 Inflammasome
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DOI: 10.3389/fphar.2022.783706
Abstract: Diabetic nephropathy (DN) is one of the primary complications of diabetes. Fisetin is a flavonoid polyphenol that is present in several vegetables and fruits. The present study investigated the mechanisms of fisetin in DN-induced podocyte… read more here.
Keywords: podocyte injury; induced podocyte; fisetin; diabetic nephropathy ... See more keywords
microRNA-20b contributes to high glucose-induced podocyte apoptosis by targeting SIRT7.
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DOI: 10.3892/mmr.2017.7224
Abstract: Previous reports have indicated that microRNAs (miRNAs) have an important role in the pathogenesis of diabetic nephropathy (DN). Podocyte apoptosis induced by high glucose (HG) is characteristic of DN. However, the role of miRNAs in… read more here.
Keywords: podocyte apoptosis; apoptosis; high glucose; induced podocyte ... See more keywords