Regulation of Cr(VI)-Induced Premature Senescence in L02 Hepatocytes by ROS-Ca2+-NF-κB Signaling
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/7295224
Abstract: Stress-induced premature senescence may be involved in the pathogeneses of acute liver injury. Hexavalent chromium [Cr(VI)], a common environmental pollutant related to liver injury, likely leads to premature senescence in L02 hepatocytes. However, the underlying… read more here.
Keywords: induced premature; senescence; premature senescence; l02 hepatocytes ... See more keywords
Clearance of Stress-Induced Premature Senescent Cells Alleviates the Formation of Abdominal Aortic Aneurysms.
Sign Up to like & getrecommendations! Published in 2023 at "Aging and disease"
DOI: 10.14336/ad.2023.0215
Abstract: Abdominal aortic aneurysm (AAA) is a multifactorial disease characterized by various pathophysiological processes, including chronic inflammation, oxidative stress, and proteolytic activity in the aortic wall. Stress-induced premature senescence (SIPS) has been implicated in regulating these… read more here.
Keywords: stress; vsmc phenotypic; abdominal aortic; stress induced ... See more keywords
Albumin-induced premature senescence in human renal proximal tubular cells and its relationship with intercellular fibrosis
Sign Up to like & getrecommendations! Published in 2022 at "Acta Biochimica et Biophysica Sinica"
DOI: 10.3724/abbs.2022055
Abstract: The presence of senescent cells is associated with renal fibrosis. This study aims to investigate the effect of albumin-induced premature senescence on tubulointerstitial fibrosis and its possible mechanism in vitro. Different concentrations of bovine serum… read more here.
Keywords: albumin induced; bsa; induced premature; senescence ... See more keywords
High Cardiorespiratory Fitness Protects against Molecular Impairments of Metabolism, Heart, and Brain with Higher Efficacy in Obesity-Induced Premature Aging
Sign Up to like & getrecommendations! Published in 2022 at "Endocrinology and Metabolism"
DOI: 10.3803/enm.2022.1430
Abstract: Background High cardiorespiratory fitness (CRF) protects against age-related diseases. However, the mechanisms mediating the protective effect of high intrinsic CRF against metabolic, cardiac, and brain impairments in non-obese versus obese conditions remain incompletely understood. We… read more here.
Keywords: obesity induced; crf; brain; induced premature ... See more keywords
Stress-induced premature senescence is associated with a prolonged QT interval and recapitulates features of cardiac aging
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DOI: 10.7150/thno.70884
Abstract: Rationale: Aging in the heart is a gradual process, involving continuous changes in cardiovascular cells, including cardiomyocytes (CMs), namely cellular senescence. These changes finally lead to adverse organ remodeling and resulting in heart failure. This… read more here.
Keywords: sencms; stress induced; induced premature; senescence ... See more keywords