Drug-Induced QT Prolongation and Torsades de Pointes: An All-Exclusive Relationship or Time for an Amicable Separation?
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DOI: 10.1007/s40264-017-0584-4
Abstract: QT prolongation was perceived as a major antiarrhythmic mechanism, but soon became a surrogate for torsades de pointes (TdP) instead. Drugs that prolong the QT interval range from having potent torsadogenic activity to no proarrhythmic… read more here.
Keywords: induced prolongation; torsades pointes; time; drug induced ... See more keywords
Drug-induced QT Prolongation Atlas (DIQTA) for enhancing cardiotoxicity management.
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DOI: 10.1016/j.drudis.2021.10.009
Abstract: Drug-induced prolongation of the QT interval is common in a variety of pharmaceutical treatments and can lead to serious clinical outcomes. Although substantial efforts have been made to prevent drug-induced QT interval prolongation, the lack… read more here.
Keywords: induced prolongation; prolongation atlas; drug induced; drug ... See more keywords
A current understanding of drug-induced QT prolongation and its implications for anticancer therapy.
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DOI: 10.1093/cvr/cvz013
Abstract: The QT interval, a global index of ventricular repolarization, varies among individuals and is influenced by diverse physiologic and pathophysiologic stimuli such as gender, age, heart rate, electrolyte concentrations, concomitant cardiac disease, and other diseases… read more here.
Keywords: induced prolongation; drug induced; drug; understanding drug ... See more keywords
Unraveling Structural Alerts in Marketed Drugs for Improving Adverse Outcome Pathway Framework of Drug-Induced QT Prolongation
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DOI: 10.3390/ijms24076771
Abstract: In pharmaceutical treatment, many non-cardiac drugs carry the risk of prolonging the QT interval, which can lead to fatal cardiac complications such as torsades de points (TdP). Although the unexpected blockade of ion channels has… read more here.
Keywords: drug induced; prolongation; induced prolongation; marketed drugs ... See more keywords
Comprehensive review on methadone-induced QT prolongation and torsades
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pharmacology and Pharmacotherapeutics"
DOI: 10.4103/jpp.jpp_163_17
Abstract: An alternative analgesic to morphine is methadone, which is used to control chronic pain and is used in opioid rehabilitation treatment programs due to methadone having a long half-life and being relatively inexpensive as compared… read more here.
Keywords: induced prolongation; methadone; review methadone; methadone induced ... See more keywords