2D DIGE proteomic analysis reveals fasting‐induced protein remodeling through organ‐specific transcription factor(s) in mice
Sign Up to like & getrecommendations! Published in 2018 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12497
Abstract: Overnight fasting is a routine procedure before surgery in clinical settings. Intermittent fasting is the most common diet/fitness trend implemented for weight loss and the treatment of lifestyle‐related diseases. In either setting, the effects not… read more here.
Keywords: protein; analysis; fasting induced; expression ... See more keywords
Modeling and Simulation of the Pharmacokinetics and Target Engagement of an Antagonist Monoclonal Antibody to Interferon‐γ–Induced Protein 10, BMS‐986184, in Healthy Participants to Guide Therapeutic Dosing
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DOI: 10.1002/cpdd.784
Abstract: BMS‐986184 is a human, second‐generation, anti–interferon‐γ–induced protein 10 (IP‐10) monoclonal antibody. In this study the pharmacokinetics and target engagement (TE) of BMS‐986184 in healthy participants were characterized using population‐based target‐mediated drug disposition (TMDD) modeling and… read more here.
Keywords: bms 986184; healthy participants; interferon induced; pharmacokinetics target ... See more keywords
An E3 ligase guide to the galaxy of small-molecule-induced protein degradation.
Sign Up to like & getrecommendations! Published in 2021 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2021.04.002
Abstract: Induced protein degradation accomplishes elimination, rather than inhibition, of pathological proteins. Key to the success of this novel therapeutic modality is the modification of proteins with ubiquitin chains, which is brought about by molecular glues… read more here.
Keywords: small molecule; protein degradation; biology; induced protein ... See more keywords
Direct Experimental Evidence of Surface-induced Protein Unfolding at the Single-molecule Level
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DOI: 10.1017/s1431927620014178
Abstract: Protein unfolding, i.e. the loss of its native tertiary (quaternary) structure, is a part of many important biological processes [1,2] and plays a big role in various biomedical and biotechnological applications [3,4]. Protein unfolding may… read more here.
Keywords: microscopy; surface; surface induced; level ... See more keywords
Plasticity in binding confers selectivity in ligand induced protein degradation
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DOI: 10.1038/s41589-018-0055-y
Abstract: Heterobifunctional small-molecule degraders that induce protein degradation through ligase-mediated ubiquitination have shown considerable promise as a new pharmacological modality. However, we currently lack a detailed understanding of the molecular basis for target recruitment and selectivity,… read more here.
Keywords: selectivity ligand; ligand induced; protein degradation; induced protein ... See more keywords
Elevated serum interferon γ-induced protein 10 kDa is associated with TAFRO syndrome
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DOI: 10.1038/srep42316
Abstract: Multicentric Castleman disease (MCD) is a heterogeneous lymphoproliferative disorder. It is characterized by inflammatory symptoms, and interleukin (IL)-6 contributes to the disease pathogenesis. Human herpesvirus 8 (HHV-8) often drives hypercytokinemia in MCD, although the etiology… read more here.
Keywords: imcd; interferon induced; induced protein; tafro imcd ... See more keywords
Interferon-Induced Protein With Multiple Tetratricopeptide Repeats 3 Is Associated With Response to Chemotherapy and Recurrence but Not With Survival.
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DOI: 10.1097/mpa.0000000000001691
Abstract: OBJECTIVES The interferon-induced protein with multiple tetratricopeptide repeats 3 (IFIT3) seems to be associated with the prognosis in pancreatic cancer. Here we clarify whether the heterogeneity of IFIT3 expression affects previous IFIT3 analysis. METHODS This… read more here.
Keywords: chemotherapy; interferon induced; induced protein; ifit3 ... See more keywords
2‐(2‐nitrobenzylidene) indolin‐3‐one compound inhibits transmembrane prostate androgen‐induced protein (TMEPAI) expression and cancer cell proliferation
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DOI: 10.1111/cpr.12469
Abstract: The transmembrane prostate androgen‐induced protein (TMEPAI) is aberrantly expressed in many cancer and plays a crucial role in tumourigenesis, which makes it a potential cancer therapeutic target for drug discovery. read more here.
Keywords: prostate androgen; transmembrane prostate; androgen induced; protein tmepai ... See more keywords
Chemically induced protein cage assembly with programmable opening and cargo release
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DOI: 10.1126/sciadv.abj9424
Abstract: An artificial protein cage can be programmed to disassemble on demand. read more here.
Keywords: induced protein; chemically induced; cage; protein cage ... See more keywords
Knockdown of Ecdysone-Induced Protein 93F Causes Abnormal Pupae and Adults in the Eggplant Lady Beetle
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DOI: 10.3390/biology11111640
Abstract: Simple Summary In several hemimetabolous, neometabolous and holometabolous insects, ecdysone-induced protein 93F (E93), a critical member among three key players (Kru ppel-homolog 1, Kr-h1; E93; Broad-complex, BrC) in the regulation of metamorphosis, exerts triple roles… read more here.
Keywords: induced protein; adult; instar; protein 93f ... See more keywords
Cardiotoxicity Induced by Protein Kinase Inhibitors in Patients with Cancer
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23052815
Abstract: Kinase inhibitors (KIs) represent a growing class of drugs directed at various protein kinases and used in the treatment of both solid tumors and hematologic malignancies. It is a heterogeneous group of compounds that are… read more here.
Keywords: protein kinase; cardiotoxicity induced; kinase inhibitors; kinase ... See more keywords