Supramolecular Nanofibers Ameliorate Bleomycin‐Induced Pulmonary Fibrosis by Restoring Autophagy
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202401327
Abstract: Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal interstitial lung disease, with limited therapeutic options available. Impaired autophagy resulting from aberrant TRB3/p62 protein‐protein interactions (PPIs) contributes to the progression of IPF. Restoration of… read more here.
Keywords: restoring autophagy; induced pulmonary; trb3; bleomycin induced ... See more keywords
A Brief Review of the Role of Macrophage Hypoxia in SiO2‐Induced Pulmonary Fibrosis
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4906
Abstract: Silicosis, a severe occupational chronic pneumonia, results from prolonged exposure to high concentrations of crystalline SiO2 in occupational environments. The inhaled SiO2 particles recruit and activate alveolar macrophages (AMs), leading to hypoxia within the AMs… read more here.
Keywords: fibrosis; induced pulmonary; role; sio2 induced ... See more keywords
Chlorogenic acid protective effects on paraquat-induced pulmonary oxidative damage and fibrosis in rats.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.23352
Abstract: Paraquat (PQ) is a widely used herbicide that can cause severe oxidative and fibrotic injuries in lung tissue. Due to the antioxidant and anti-inflammatory properties of chlorogenic acid (CGA), the present study investigated its effects… read more here.
Keywords: lung tissue; acid protective; cga; chlorogenic acid ... See more keywords
Integrated analysis of ceRNA‐miRNA changes in paraquat‐induced pulmonary epithelial‐mesenchymal transition via high‐throughput sequencing
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23681
Abstract: Recent studies have shown that epithelial‐mesenchymal transition (EMT) plays an important role in paraquat (PQ)‐induced tissue fibrosis, which is the main cause of death in patients with PQ poisoning. However, no effective treatment for pulmonary… read more here.
Keywords: mesenchymal transition; paraquat induced; induced pulmonary; mirna ... See more keywords
Grading Bleomycin‐Induced Pulmonary Fibrosis in ex vivo Mouse Lungs Using Ultrasound Image Analysis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Ultrasound in Medicine"
DOI: 10.1002/jum.15448
Abstract: The aim of this study was to assess bleomycin‐induced pulmonary fibrosis on ex vivo mouse lungs using ultrasound image grading and texture analysis. read more here.
Keywords: bleomycin induced; fibrosis vivo; mouse lungs; induced pulmonary ... See more keywords
Vitamin D protects against particles‐caused lung injury through induction of autophagy in an Nrf2‐dependent manner
Sign Up to like & getrecommendations! Published in 2019 at "Environmental Toxicology"
DOI: 10.1002/tox.22726
Abstract: Fine particulate matter is a well‐known air pollutant threatening public health. Studies have confirmed long‐term exposure to the particles could decrease the pulmonary function, induce asthma exacerbation, and chronic obstructive pulmonary disease, as well as… read more here.
Keywords: nrf2 dependent; autophagy nrf2; induced pulmonary; induction autophagy ... See more keywords
Pachymic acid ameliorates bleomycin-induced pulmonary fibrosis through inhibiting endoplasmic reticulum stress in rats.
Sign Up to like & getrecommendations! Published in 2023 at "Environmental toxicology"
DOI: 10.1002/tox.23824
Abstract: The effect of pachymic acid (PA) on pulmonary fibrosis in rats was expected to be investigated in this study. Firstly, bleomycin (BLM) was used to establish pulmonary fibrosis rat model, then PA (10, 20, or… read more here.
Keywords: lung tissue; blm; pulmonary fibrosis; induced pulmonary ... See more keywords
Ibrutinib Exacerbates Bleomycin-Induced Pulmonary Fibrosis via Promoting Inflammation
Sign Up to like & getrecommendations! Published in 2018 at "Inflammation"
DOI: 10.1007/s10753-018-0745-3
Abstract: Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible lung disease with high mortality rate. The etiology is unknown and treatment choices are limited. Thus, there is great interest to investigate novel agents for IPF… read more here.
Keywords: bleomycin induced; ibrutinib; fibrosis; induced pulmonary ... See more keywords
Interleukin-37 Attenuates Bleomycin-Induced Pulmonary Inflammation and Fibrosis in Mice
Sign Up to like & getrecommendations! Published in 2018 at "Inflammation"
DOI: 10.1007/s10753-018-0820-9
Abstract: Pulmonary fibrosis is a disease with chronic inflammation and excessive collagen deposition for which there is no effective treatments. Interleukin (IL)-37 is a newly identified anti-inflammatory cytokine but its role in pulmonary fibrosis remains unclear.… read more here.
Keywords: bleomycin induced; fibrosis; induced pulmonary; fibrosis mice ... See more keywords
p38 Inhibition Ameliorates Inspiratory Resistive Breathing-Induced Pulmonary Inflammation
Sign Up to like & getrecommendations! Published in 2018 at "Inflammation"
DOI: 10.1007/s10753-018-0831-6
Abstract: Inspiratory resistive breathing (IRB), a hallmark of obstructive airway diseases, is associated with strenuous contractions of the inspiratory muscles and increased negative intrathoracic pressures that act as an injurious stimulus to the lung. We have… read more here.
Keywords: pulmonary inflammation; inspiratory resistive; induced pulmonary; inflammation ... See more keywords
Metabolomic study on bleomycin and polyhexamethylene guanidine phosphate-induced pulmonary fibrosis mice models
Sign Up to like & getrecommendations! Published in 2019 at "Metabolomics"
DOI: 10.1007/s11306-019-1574-6
Abstract: Polyhexamethylene guanidine phosphate (PHMG) has been used as a disinfectant and biocide, and was known to be harmless and non-toxic. However, in 2011, PHMG used as a humidifier disinfectant was reported to be associated with… read more here.
Keywords: guanidine phosphate; fibrosis; induced pulmonary; polyhexamethylene guanidine ... See more keywords