Role of Phosphatidylinositol-3 Kinase Pathway in NMDA Preconditioning: Different Mechanisms for Seizures and Hippocampal Neuronal Degeneration Induced by Quinolinic Acid
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DOI: 10.1007/s12640-018-9903-5
Abstract: N-methyl D-aspartate (NMDA) preconditioning is evoked by the administration of a subtoxic dose of NMDA and is protective against neuronal excitotoxicity. This effect may involve a diversity of targets and cell signaling cascades associated to… read more here.
Keywords: neuronal degeneration; phosphatidylinositol kinase; seizures hippocampal; induced quinolinic ... See more keywords
Sustained Activation of JNK Induced by Quinolinic Acid Alters the BDNF/TrkB Axis in the Rat Striatum
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DOI: 10.1016/j.neuroscience.2018.04.034
Abstract: Oxidative stress secondary to excitotoxicity is a common factor in the physiopathology of a variety of neurological disorders. In response to oxidative stress, several signaling pathways, such as MAPK, are activated or inactivated. Mitogen-activated protein… read more here.
Keywords: jnk; quin; bdnf trkb; induced quinolinic ... See more keywords