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   Articles with "induced regulatory" as a keyword



STAT6 inhibition stabilizes induced regulatory T cells and enhances their therapeutic potential in inflammatory bowel disease

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recommendations! Published in 2025 at "Immunologic Research"

DOI: 10.1007/s12026-025-09686-7

Abstract: The development and stability of induced regulatory T cells (iTregs) are essential for their immunosuppressive function and therapeutic potential in inflammatory diseases. Although Treg-based immunotherapy offers promise for restoring immune tolerance, clinical application is limited… read more here.

Keywords: induced regulatory; regulatory cells; stability; inhibition ... See more keywords

MANAGERS’ PURSUIT OF AMBIDEXTERITY IN THE CONTEXT OF ARTIFICIAL INTELLIGENCE IMPLEMENTATIONS: INSIGHTS INTO SITUATIONALLY INDUCED REGULATORY FOCUS

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recommendations! Published in 2024 at "International Journal of Innovation Management"

DOI: 10.1142/s1363919623500512

Abstract: This study identifies a key cognitive mechanism through which information encountered by managers influences their pursuit of ambidexterity when implementing artificial intelligence (AI) in organisations. Additionally, it investigates the roles of managers’ understanding of technological… read more here.

Keywords: induced regulatory; situationally induced; ambidexterity; pursuit ambidexterity ... See more keywords
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First-in-human phase 1 trial of induced regulatory T cells for graft-versus-host disease prophylaxis in HLA-matched siblings.

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recommendations! Published in 2021 at "Blood advances"

DOI: 10.1182/bloodadvances.2020003219

Abstract: Human CD4+25- T cells cultured in interleukin 2 (IL-2), rapamycin, and transforming growth factor β (TGFβ) along with anti-CD3 monoclonal antibody-loaded artificial antigen-presenting cells generate FoxP3+ induced regulatory T cells (iTregs) with potent suppressive function.… read more here.

Keywords: csa mmf; versus host; regulatory cells; induced regulatory ... See more keywords

Natural IgM and TLR Agonists Switch Murine Splenic Pan-B to “Regulatory” Cells That Suppress Ischemia-Induced Innate Inflammation via Regulating NKT-1 Cells

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recommendations! Published in 2017 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2017.00974

Abstract: Natural IgM anti-leukocyte autoantibodies (IgM-ALAs) inhibit inflammation by several mechanisms. Here, we show that pan-B cells and bone marrow-derived dendritic cells (BMDCs) are switched to regulatory cells when pretreated ex vivo with IgM. B cells… read more here.

Keywords: natural igm; inflammation; regulatory cells; induced regulatory ... See more keywords

Microbiota-induced regulatory T cells associate with FUT2-dependent susceptibility to rotavirus gastroenteritis

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recommendations! Published in 2023 at "Frontiers in Microbiology"

DOI: 10.3389/fmicb.2023.1123803

Abstract: The FUT2 α1,2fucosyltransferase contributes to the synthesis of fucosylated glycans used as attachment factors by several pathogens, including noroviruses and rotaviruses, that can induce life-threatening gastroenteritis in young children. FUT2 genetic polymorphisms impairing fucosylation are… read more here.

Keywords: regulatory cells; microbiota; gastroenteritis; induced regulatory ... See more keywords