(-)-Stepholidine reduces cue-induced reinstatement of cocaine seeking and cocaine self-administration in rats.
Sign Up to like & getrecommendations! Published in 2018 at "Drug and alcohol dependence"
DOI: 10.1016/j.drugalcdep.2018.04.030
Abstract: BACKGROUND Dopamine receptors are implicated in cocaine reward and seeking. We hypothesize that (-)-stepholidine, a dopamine D1/D2/D3 multi-receptor agent, would be effective in reducing cocaine reward and seeking in an animal model. We investigated the… read more here.
Keywords: cue induced; cue; cocaine seeking; reinstatement cocaine ... See more keywords
The effects of dopamine D4 receptor ligands on operant alcohol self-administration and cue- and stress-induced reinstatement in rats.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2019.172838
Abstract: Dopamine, a neurotransmitter with 5 receptor subtypes, is critical to the dependence-forming properties of drugs of abuse. The role of the dopamine D4 receptor subtype in substance use disorders has remained somewhat elusive but the… read more here.
Keywords: dopamine receptor; stress; receptor; alcohol ... See more keywords
Effects of ketosis on cocaine-induced reinstatement in male mice
Sign Up to like & getrecommendations! Published in 2022 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2022.136619
Abstract: In recent years, the benefits of the ketogenic diet (KD) on different psychiatric disorders have been gaining attention, but the substance abuse field is still unexplored. Some studies have reported that palatable food can modulate… read more here.
Keywords: effects cocaine; induced reinstatement; effects ketosis; ketosis cocaine ... See more keywords
Sex differences in the effect of the FKBP5 inhibitor SAFit2 on anxiety and stress-induced reinstatement following cocaine self-administration
Sign Up to like & getrecommendations! Published in 2020 at "Neurobiology of Stress"
DOI: 10.1016/j.ynstr.2020.100232
Abstract: Cocaine use and withdrawal prompt stress system responses. Stress and the negative affective state produced by cocaine withdrawal are major triggers for relapse. FKBP5 is a co-chaperone of the glucocorticoid receptor and regulates HPA axis… read more here.
Keywords: administration; stress induced; stress; cocaine ... See more keywords
Glutamatergic Projections from the Entorhinal Cortex to Dorsal Dentate Gyrus Mediate Context-Induced Reinstatement of Heroin Seeking
Sign Up to like & getrecommendations! Published in 2017 at "Neuropsychopharmacology"
DOI: 10.1038/npp.2017.14
Abstract: Reexposure to the context associated with heroin intake provokes relapse to drug taking after abstinence. The dorsal dentate gyrus (dDG) and entorhinal cortex (EC) have been implicated in contextual memory processing, but the underlying circuit… read more here.
Keywords: context; reinstatement heroin; heroin seeking; context induced ... See more keywords
Perineuronal nets in the lateral hypothalamus area regulate cue-induced reinstatement of cocaine-seeking behavior
Sign Up to like & getrecommendations! Published in 2018 at "Neuropsychopharmacology"
DOI: 10.1038/s41386-018-0212-8
Abstract: We previously reported that a small, circumscribed region of the lateral hypothalamus, the anterior dorsal region (LHAad), stains heavily for PNNs and dense extracellular matrix (PNNs/ECM) with Wisteria floribunda agglutinin (WFA), and critically contributes to… read more here.
Keywords: cue induced; seeking behavior; reinstatement cocaine; cocaine ... See more keywords
From head to tail (of the VTA): role of projections from prelimbic cortex to rostromedial tegmental nucleus in cocaine reinstatement
Sign Up to like & getrecommendations! Published in 2021 at "Neuropsychopharmacology"
DOI: 10.1038/s41386-020-00933-z
Abstract: Research into the neurobiological mechanisms of drug seeking has expanded recently, in part because of the development of neuroscience techniques that target and manipulate neuronal activity. Studies using these techniques, together with studies using more… read more here.
Keywords: cocaine seeking; role; rmtg; cocaine ... See more keywords
CB1R activation in nucleus accumbens core promotes stress-induced reinstatement of cocaine seeking by elevating extracellular glutamate in a drug-paired context
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-92389-4
Abstract: Preclinical models of stress-induced relapse to drug use have shown that the dysregulation of glutamatergic transmission within the nucleus accumbens (NA) contributes notably to the reinstatement of cocaine-seeking behavior in rodents. In this sense, there… read more here.
Keywords: cb1r; extracellular glutamate; stress induced; reinstatement cocaine ... See more keywords
Blockade of orexin receptors in the infralimbic cortex prevents stress‐induced reinstatement of alcohol‐seeking behaviour in alcohol‐dependent rats
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Pharmacology"
DOI: 10.1111/bph.16015
Abstract: A major problem managing alcohol use disorder is the high vulnerability to relapse, even after long periods of abstinence. Chronic alcohol use dysregulates stress responsivity, rendering this system hyporesponsive and making individuals vulnerable to relapse.… read more here.
Keywords: infralimbic cortex; induced reinstatement; stress induced; alcohol ... See more keywords
Role of mu, but not delta or kappa, opioid receptors in context‐induced reinstatement of oxycodone seeking
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.13955
Abstract: Relapse to non‐medical use of prescription opioids often occurs after exposure to places previously associated with drug use. Here, we describe a rat model of context‐induced reinstatement of oxycodone seeking after repeated cycles of drug… read more here.
Keywords: reinstatement; oxycodone seeking; reinstatement oxycodone; context induced ... See more keywords
Role of Orexin-1 Receptor Within the Ventral Tegmental Area in Mediating Stress- and Morphine Priming-induced Reinstatement of Conditioned Place Preference in Rats
Sign Up to like & getrecommendations! Published in 2019 at "Basic and Clinical Neuroscience"
DOI: 10.32598/bcn.9.10.130
Abstract: Introduction: Orexin-containing neurons exist in the lateral hypothalamic region, sending their projections toward mesolimbic regions such as the Ventral Tegmental Area (VTA). Methods: In the current study, a Reinstatement model is used to examine the… read more here.
Keywords: priming induced; orexin; reinstatement; morphine ... See more keywords