Vanillin attenuates thioacetamide‐induced renal assault by direct and indirect mediation of the TGFβ, ERK and Smad signalling pathways in rats
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3686
Abstract: Inflammation and fibrosis are two pathological features of chronic kidney disease (CKD). Renal fibrosis is considered to be one of the most important conditions, as it may be the result of excessive extracellular matrix protein… read more here.
Keywords: vanillin attenuates; kidney; induced renal; smad ... See more keywords
Sclareol ameliorates hyperglycemia‐induced renal injury through inhibiting the MAPK/NF‐κB signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7465
Abstract: Diabetic nephropathy (DN) represents the most serious complication of diabetes. Previous studies have shown that the activation of nuclear factor kappa B (NF‐κB) and mitogen‐activated protein kinase (MAPK) are linked to inflammation in the development… read more here.
Keywords: signaling pathway; induced renal; mapk signaling; pathway sclareol ... See more keywords
[Contrast medium-induced renal failure : Useful protective measures prior to contrast medium administration].
Sign Up to like & getrecommendations! Published in 2019 at "Der Internist"
DOI: 10.1007/s00108-019-0651-2
Abstract: BACKGROUND Iodinated contrast is essential for diagnosis and treatment in contemporary interventional cardiology. An important complication of percutaneous intervention is contrast-induced nephropathy, which is associated with increased morbidity and mortality, while prolonged hospitalization is responsible… read more here.
Keywords: contrast; medium induced; contrast medium; contrast induced ... See more keywords
Apamin inhibits renal fibrosis via suppressing TGF-β1 and STAT3 signaling in vivo and in vitro.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular medicine"
DOI: 10.1007/s00109-021-02087-x
Abstract: Renal fibrosis is a progressive and chronic process that influences kidneys with chronic kidney disease (CKD), irrespective of cause, leading to irreversible failure of renal function and end-stage kidney disease. Among the signaling related to… read more here.
Keywords: fibrosis; renal fibrosis; activation; induced renal ... See more keywords
Gallic acid exerts anti-inflammatory, anti-oxidative stress, and nephroprotective effects against paraquat-induced renal injury in male rats
Sign Up to like & getrecommendations! Published in 2020 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-020-01931-0
Abstract: Paraquat (PRQ) is a toxic chemical compound that is very noxious to animals and humans. Gallic acid is a phenolic compound that has antioxidant properties. In this study, we evaluated the ameliorative effect of gallic… read more here.
Keywords: gallic acid; group; renal injury; induced renal ... See more keywords
Calcitriol Ameliorates AngiotensinII-Induced Renal Injury Partly via Upregulating A20
Sign Up to like & getrecommendations! Published in 2017 at "Inflammation"
DOI: 10.1007/s10753-017-0629-y
Abstract: Inflammation and reactive oxygen species (ROS) play crucial roles in the progression of chronic kidney diseases. Vitamin D has been shown anti-inflammatory effects, but the underlying mechanism is not fully understood. Here, we investigated whether… read more here.
Keywords: calcitriol; renal injury; a20; induced renal ... See more keywords
Ameliorative role of bosentan, an endothelin receptor antagonist, against sodium arsenite–induced renal dysfunction in rats
Sign Up to like & getrecommendations! Published in 2020 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-020-11035-0
Abstract: Arsenic exposure is well documented to cause serious health hazards, such as cardiovascular abnormalities, neurotoxicity and nephrotoxicity. In the present study, we intended to explore the role of bosentan, an endothelial receptor antagonist, against sodium… read more here.
Keywords: sodium arsenite; induced renal; role bosentan; arsenite induced ... See more keywords
Danshen modulates Nrf2-mediated signaling pathway in cisplatin-induced renal injury
Sign Up to like & getrecommendations! Published in 2017 at "Current Medical Science"
DOI: 10.1007/s11596-017-1801-1
Abstract: SummaryDanshen, an efficacious agent for cardiovascular diseases, has been found to play an essential role in kidney injury. In the present study, the effect of Danshen on cisplatin-induced renal dysfunction was investigated in a mouse… read more here.
Keywords: cisplatin; danshen; nrf2 mediated; induced renal ... See more keywords
CTRP1 Attenuates UUO-induced Renal Fibrosis via AMPK/NOX4 Pathway in Mice
Sign Up to like & getrecommendations! Published in 2020 at "Current Medical Science"
DOI: 10.1007/s11596-020-2145-9
Abstract: C1q/TNF-related protein 1 (CTRP1), a conserved protein of the C1q family, plays a key role in cardiovascular and metabolic diseases. However, the role of CTRP1 in renal injury is unclear. The purpose of this study… read more here.
Keywords: ctrp1; renal fibrosis; induced renal; mice ... See more keywords
Pharmacological inhibition of Rac1 exerts a protective role in ischemia/reperfusion-induced renal fibrosis.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.07.009
Abstract: Acute kidney injury induced by renal ischemia-reperfusion (IR) is a prominent risk factor in the development towards renal fibrosis. Ras-related C3 botulinum toxin substrate 1(Rac1) has been involved in the pathophysiology of fibrotic disorders. But… read more here.
Keywords: fibrosis; inhibition; renal fibrosis; role ... See more keywords
Carvacrol exerts nephroprotective effect in rat model of diclofenac-induced renal injury through regulation of oxidative stress and suppression of inflammatory response
Sign Up to like & getrecommendations! Published in 2021 at "Heliyon"
DOI: 10.1016/j.heliyon.2021.e08358
Abstract: Diclofenac (DIC) is an NSAID that can cause toxic effects in animals and humans and carvacrol (CAR) is a monoterpene compound that displays effective pharmacological and biological actions. The purpose of this work was to… read more here.
Keywords: group; renal injury; induced renal; car ... See more keywords