Opioid-induced respiratory depression in humans: a review of pharmacokinetic-pharmacodynamic modelling of reversal.
Sign Up to like & getrecommendations! Published in 2019 at "British journal of anaesthesia"
DOI: 10.1016/j.bja.2018.12.023
Abstract: BACKGROUND Opioids are potent painkillers but come with serious adverse effects ranging from addiction to potentially lethal respiratory depression. A variety of drugs with separate mechanisms of action are available to prevent or reverse opioid-induced… read more here.
Keywords: induced respiratory; reversal; opioid induced; respiratory depression ... See more keywords
Inhibition of protein kinase A and GIRK channel reverses fentanyl-induced respiratory depression
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2018.04.029
Abstract: Opioid-induced respiratory depression is a major obstacle to improving the clinical management of moderate to severe chronic pain. Opioids inhibit neuronal activity via various pathways, including calcium channels, adenylyl cyclase, and potassium channels. Currently, the… read more here.
Keywords: depression; induced respiratory; fentanyl induced; respiratory depression ... See more keywords
Developing an animal model to detect drug–drug interactions impacting drug-induced respiratory depression⋆
Sign Up to like & getrecommendations! Published in 2020 at "Toxicology Reports"
DOI: 10.1016/j.toxrep.2020.01.008
Abstract: Highlights • A model to assess drug interaction effects on drug induced respiratory depression.• Plasma oxycodone level AUC was 113 % higher when the two drugs were co-administered.• Diazepam showed synergistic effects on respiratory depression… read more here.
Keywords: induced respiratory; drug induced; drug; model ... See more keywords
Severe and persistent morphine-induced respiratory depression associated with ATP-Binding Cassette Subfamily B Member 1 and catechol-O-methyltransferase genetic defects: A case report.
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Anaesthesiology"
DOI: 10.1097/eja.0000000000000801
Abstract: Our data are in line with studies using single direct assessment of intravascular volume or functional assessments. Single measurements preclude detection of individual changes. We have assessed such changes and demonstrate that no clinically relevant… read more here.
Keywords: persistent morphine; morphine induced; severe persistent; induced respiratory ... See more keywords
High Dose of Pralidoxime Reverses Paraoxon-Induced Respiratory Toxicity in Mice.
Sign Up to like & getrecommendations! Published in 2018 at "Turkish journal of anaesthesiology and reanimation"
DOI: 10.5152/tjar.2018.29660
Abstract: Objective The efficiency of pralidoxime in the treatment of human organophosphates poisoning is still unclear. In a rat model, we showed that pralidoxime induced a complete but concentration-dependent reversal of paraoxon-induced respiratory toxicity. The aim… read more here.
Keywords: paraoxon induced; induced respiratory; toxicity; pralidoxime ... See more keywords