A new function for the serine protease HtrA2 in controlling radiation‐induced senescence in cancer cells
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13187
Abstract: Radiation therapy can induce cellular senescence in cancer cells, leading to short‐term tumor growth arrest but increased long‐term recurrence. To better understand the molecular mechanisms involved, we developed a model of radiation‐induced senescence in cultured… read more here.
Keywords: htra2; senescence; radiation; radiation induced ... See more keywords
Autophagy Detection During Oncogene-Induced Senescence Using Fluorescence Microscopy.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6670-7_8
Abstract: Oncogene-induced senescence (OIS) is a highly dynamic process, involving several different effector mechanisms, the multitude and combination of which likely determines the quality of the phenotype (Pérez-Mancera et al., Nat Rev Cancer 14:547-558, 2014). Autophagy,… read more here.
Keywords: methods mol; oncogene induced; microscopy; senescence ... See more keywords
DELLA proteins negatively regulate dark-induced senescence and chlorophyll degradation in Arabidopsis through interaction with the transcription factor WRKY6
Sign Up to like & getrecommendations! Published in 2018 at "Plant Cell Reports"
DOI: 10.1007/s00299-018-2282-9
Abstract: Key messageDELLA proteins’ negative regulation of dark-induced senescence and chlorophyll degradation in Arabidopsis is through interaction with WRKY6 and thus repression of its transcriptional activities on senescence-related genes.AbstractSenescence is an intricate and highly orchestrated process… read more here.
Keywords: senescence; dark induced; dark; chlorophyll ... See more keywords
PIM1-catalyzed CBX8 phosphorylation promotes the oncogene-induced senescence of human diploid fibroblast.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.05.070
Abstract: The proto-oncogene PIM1 encodes Ser/Thr kinase and regulates cell growth, differentiation and apoptosis. However, more and more studies including ours have found that PIM1 can induce senescence in normal human diploid fibroblasts and behave as… read more here.
Keywords: pim1; cbx8; senescence; induced senescence ... See more keywords
Abrogation of B-RafV600E induced senescence by FoxM1 expression.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.06.144
Abstract: B-RafV600E oncogene mutation occurs in various cancers and is associated with tumor initiation. However, genetic modification of B-RafV600E in cells induces MAPK activation and results in oncogene-induced senescence. Overcoming the oncogene-induced senescence by B-RafV600E requires… read more here.
Keywords: foxm1 expression; rafv600e; induced senescence; senescence ... See more keywords
The role of the NORE1A tumor suppressor in Oncogene-Induced Senescence.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer letters"
DOI: 10.1016/j.canlet.2017.04.030
Abstract: The Ras genes are the most frequently mutated oncogenes in human cancer. However, Ras biology is quite complex. While Ras promotes tumorigenesis by regulating numerous growth promoting pathways, activated Ras can paradoxically also lead to… read more here.
Keywords: oncogene induced; role nore1a; nore1a tumor; induced senescence ... See more keywords
Identification and expression analysis of 11 subtilase genes during natural and induced senescence of barley plants.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of plant physiology"
DOI: 10.1016/j.jplph.2017.01.005
Abstract: Subtilases are one of the largest groups of the serine protease family and are involved in many aspects of plant development including senescence. In wheat, previous reports demonstrate an active participation of two senescence-induced subtilases,… read more here.
Keywords: barley; senescence; expression; induced senescence ... See more keywords
Ceramide-1-Phosphate Is Involved in Therapy-Induced Senescence.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical biology"
DOI: 10.1021/acschembio.2c00216
Abstract: Sphingolipids are key signaling lipids and their dysregulation has been associated with various cellular processes. We have previously shown significant changes in sphingolipids in therapy-induced senescence, a state of cell cycle arrest as a response… read more here.
Keywords: induced senescence; therapy induced; therapy; ceramide phosphate ... See more keywords
Convergence of therapy-induced senescence (TIS) and EMT in multistep carcinogenesis: current opinions and emerging perspectives.
Sign Up to like & getrecommendations! Published in 2020 at "Cell death discovery"
DOI: 10.1038/s41420-020-0286-z
Abstract: Drug induced resistance is a widespread problem in the clinical management of cancer. Cancer cells, when exposed to cytotoxic drugs, can reprogram their cellular machinery and resist cell death. Evasion of cell death mechanisms, such… read more here.
Keywords: emt; senescence; cell death; induced senescence ... See more keywords
BRAFV600E-induced senescence drives Langerhans cell histiocytosis pathophysiology.
Sign Up to like & getrecommendations! Published in 2021 at "Nature medicine"
DOI: 10.1038/s41591-021-01304-x
Abstract: Langerhans cell histiocytosis (LCH) is a potentially fatal condition characterized by granulomatous lesions with characteristic clonal mononuclear phagocytes (MNPs) harboring activating somatic mutations in mitogen-activated protein kinase (MAPK) pathway genes, most notably BRAFV600E. We recently… read more here.
Keywords: langerhans cell; senescence; cell histiocytosis; brafv600e ... See more keywords
Cyclooxygenase-2 induces neoplastic transformation by inhibiting p53-dependent oncogene-induced senescence
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-89220-5
Abstract: Much in vivo evidence indicates that cyclooxygenase-2 (COX-2) is deeply involved in tumorigenesis. Although it has been proposed that COX-2-derived pro-inflammatory prostanoids mediate the tumorigenic activity of COX-2, the tumorigenic mechanisms of COX-2 are not… read more here.
Keywords: oncogene induced; neoplastic transformation; cox; induced senescence ... See more keywords