Dynamics of Various Phospholipase C-B Complexes
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.526
Abstract: Phospholipase C-β (PLCβ) is activated by G protein signals from different hormones and neurotransmitters on the plasma membrane, to mediate increases in intracellular calcium. Surprisingly, we find that PLCβ also localizes to the cytoplasm where… read more here.
Keywords: induced silencing; dynamics various; phospholipase; various phospholipase ... See more keywords
Rational optimization of siRNA to ensure strand bias in the interaction with the RNA-induced silencing complex.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d3cc01143g
Abstract: To ensure specificity of small interfering RNAs (siRNAs), the antisense strand must be selected by the RNA-induced silencing complex (RISC). We have previously demonstrated that a 5'-morpholino-modified nucleotide at the 5'-end of the sense strand… read more here.
Keywords: silencing complex; strand; induced silencing; rna induced ... See more keywords
Abstract 479: Modeling miRNA induced silencing in breast cancer with PARADIGM
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-479
Abstract: Introduction: MicroRNAs play an important role in regulation of gene expression and are known biomarkers for breast cancer as well as other malignancies. PARADIGM is a pathway based algorithm that allows for integration of multiple… read more here.
Keywords: mirna; induced silencing; breast cancer; cancer ... See more keywords
In Arabidopsis thaliana, RNA-Induced Silencing Complex-Loading of MicroRNAs Plays a Minor Regulatory Role During Photomorphogenesis Except for miR163
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.854869
Abstract: The shift of dark-grown seedlings to the light leads to substantial reprogramming of gene expression, which results in dramatic developmental changes (referred to as de-etiolation or photomorphogenesis). MicroRNAs (miRNAs) regulate most steps of plant development,… read more here.
Keywords: induced silencing; role; photomorphogenesis; rna induced ... See more keywords