T1AM-TAAR1 signalling protects against OGD-induced synaptic dysfunction in the entorhinal cortex
Sign Up to like & getrecommendations! Published in 2021 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2021.105271
Abstract: Abnormalities in thyroid hormones (TH) availability and/or metabolism have been hypothesized to contribute to Alzheimer's disease (AD) and to be a risk factor for stroke. Recently, 3-iodothyronamine (T1AM), an endogenous amine putatively derived from TH… read more here.
Keywords: entorhinal cortex; t1am; induced synaptic; effect ... See more keywords
Therapeutic Dose of Hydroxyurea-Induced Synaptic Abnormalities on the Mouse Spermatocyte
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2021.666339
Abstract: Hydroxyurea (HU) is a widely used pharmacological therapy for sickle cell disease (SCD). However, replication stress caused by HU has been shown to inhibit premeiotic S-phase DNA, leading to reproductive toxicity in germ cells. In… read more here.
Keywords: therapeutic dose; induced synaptic; dose hydroxyurea; hydroxyurea ... See more keywords
REDD1 Is Involved in Amyloid β-Induced Synaptic Dysfunction and Memory Impairment
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21249482
Abstract: Alzheimer’s disease (AD) is a neurodegenerative disease characterized by neurological dysfunction, including memory impairment, attributed to the accumulation of amyloid β (Aβ) in the brain. Although several studies reported possible mechanisms involved in Aβ pathology,… read more here.
Keywords: induced synaptic; redd1; pathology; synaptic dysfunction ... See more keywords