T1AM-TAAR1 signalling protects against OGD-induced synaptic dysfunction in the entorhinal cortex
Sign Up to like & getrecommendations! Published in 2021 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2021.105271
Abstract: Abnormalities in thyroid hormones (TH) availability and/or metabolism have been hypothesized to contribute to Alzheimer's disease (AD) and to be a risk factor for stroke. Recently, 3-iodothyronamine (T1AM), an endogenous amine putatively derived from TH… read more here.
Keywords: entorhinal cortex; t1am; induced synaptic; effect ... See more keywords
Identification of secretory autophagy as a mechanism modulating activity-induced synaptic remodeling
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2315958121
Abstract: Significance Neurons are endowed with the capacity to rapidly remodel their synaptic structure and strength in response to varying stimuli. This process, known as activity-induced synaptic remodeling, is crucial for the brain’s ability to transform… read more here.
Keywords: secretory autophagy; synaptic remodeling; activity induced; induced synaptic ... See more keywords
Transcriptomic and de novo proteomic analyses of organotypic entorhino-hippocampal tissue cultures reveal changes in metabolic and signaling regulators in TTX-induced synaptic plasticity
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Brain"
DOI: 10.1186/s13041-024-01153-y
Abstract: Understanding the mechanisms of synaptic plasticity is crucial for elucidating how the brain adapts to internal and external stimuli. A key objective of plasticity is maintaining physiological activity states during perturbations by adjusting synaptic transmission… read more here.
Keywords: ttx induced; entorhino hippocampal; plasticity; organotypic entorhino ... See more keywords
Therapeutic Dose of Hydroxyurea-Induced Synaptic Abnormalities on the Mouse Spermatocyte
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2021.666339
Abstract: Hydroxyurea (HU) is a widely used pharmacological therapy for sickle cell disease (SCD). However, replication stress caused by HU has been shown to inhibit premeiotic S-phase DNA, leading to reproductive toxicity in germ cells. In… read more here.
Keywords: therapeutic dose; induced synaptic; dose hydroxyurea; hydroxyurea ... See more keywords
REDD1 Is Involved in Amyloid β-Induced Synaptic Dysfunction and Memory Impairment
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21249482
Abstract: Alzheimer’s disease (AD) is a neurodegenerative disease characterized by neurological dysfunction, including memory impairment, attributed to the accumulation of amyloid β (Aβ) in the brain. Although several studies reported possible mechanisms involved in Aβ pathology,… read more here.
Keywords: induced synaptic; redd1; pathology; synaptic dysfunction ... See more keywords