Old age potentiates cold-induced tau phosphorylation: linking thermoregulatory deficit with Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2016.09.024
Abstract: Thermoregulatory deficits coincide with a rise in the incidence of Alzheimer's disease (AD) in old age. Lower body temperature increases tau phosphorylation, a neuropathological hallmark of AD. To determine whether old age potentiates cold-induced tau… read more here.
Keywords: induced tau; cold induced; old age; tau phosphorylation ... See more keywords
Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer’s and Pick’s diseases
Sign Up to like & getrecommendations! Published in 2019 at "eLife"
DOI: 10.7554/elife.43584
Abstract: Assembly of microtubule-associated protein tau into filamentous inclusions underlies a range of neurodegenerative diseases. Tau filaments adopt different conformations in Alzheimer’s and Pick’s diseases. Here, we used cryo- and immuno- electron microscopy to characterise filaments… read more here.
Keywords: induced tau; alzheimer pick; heparin induced; pick diseases ... See more keywords