Tranilast abrogates cisplatin‐induced testicular and epididymal injuries: An insight into its modulatory impact on apoptosis/proliferation
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22817
Abstract: Cisplatin is a chemotherapeutic agent whose therapeutic use is greatly limited by the associated organs' toxicity and particularly, testicular toxicity. Cisplatin‐induced testicular damage reported being mediated through mitochondria‐mediated apoptosis, inflammation, and oxidative stress. Evidence showed… read more here.
Keywords: epididymal injuries; proliferation; induced testicular; cisplatin induced ... See more keywords
Di‐(2‐ethylhexyl) phthalate (DEHP)‐induced testicular toxicity through Nrf2‐mediated Notch1 signaling pathway in Sprague–Dawley rats
Sign Up to like & getrecommendations! Published in 2018 at "Environmental Toxicology"
DOI: 10.1002/tox.22559
Abstract: Di‐(2‐ethylhexyl) phthalate (DEHP) is an environmental endocrine disruptor widely used in China that is harmful to the male reproductive system. Many studies have shown that DEHP causes testicular toxicity through oxidative stress, but the specific… read more here.
Keywords: dehp induced; testicular toxicity; toxicity; pathway ... See more keywords
Hypomethylation of LINE-1 retrotransposons is associated with cadmium-induced testicular injury
Sign Up to like & getrecommendations! Published in 2020 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-020-10115-5
Abstract: Retrotransposons, as vital regulator of male fertility, are essential for spermatogenesis. Cadmium (Cd) is an environmental toxicant and endocrine disruptor, targeting the reproductive system. Growing evidence shows that Cd exposure can induce male infertility in… read more here.
Keywords: hypomethylation line; cadmium; induced testicular; testicular injury ... See more keywords
Protective Effect of Ganoderma Triterpenoids on Cadmium-Induced Testicular Toxicity in Chickens
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DOI: 10.1007/s12011-018-1364-4
Abstract: Studies have shown that cadmium can cause chicken testicular damage, but a protective effect of Ganoderma triterpenoids on cadmium-induced testicular damage in chickens has not yet been reported. The present study was designed to research… read more here.
Keywords: cadmium induced; protective effect; ganoderma; cadmium ... See more keywords
Cadmium-Induced Testicular Toxicity in Mice: Subacute and Subchronic Route-Dependent Effects
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DOI: 10.1007/s12011-019-01731-5
Abstract: This study aimed to compare Cd exposure by intraperitoneal ( i.p. ) and oral routes, evaluating the testicular subacute and subchronic effects. Adult male mice were separated into three groups subdivided according to the experimental… read more here.
Keywords: oral routes; subacute subchronic; mice; induced testicular ... See more keywords
Melatonin Ameliorates LPS-Induced Testicular Nitro-oxidative Stress (iNOS/TNFα) and Inflammation (NF-kB/COX-2) via Modulation of SIRT-1
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DOI: 10.1007/s43032-021-00597-0
Abstract: Lipopolysaccharide (LPS) — an endotoxin that is being extensively used in laboratory to mimic microbial infection that adversely affects male fertility. This study investigated the protective effects of melatonin on LPS-induced testicular nitro-oxidative stress, inflammation,… read more here.
Keywords: lps induced; nitro oxidative; induced testicular; melatonin ... See more keywords
Amelioration of cadmium-induced testes' damage in rats by the bone marrow mesenchymal stem cells.
Sign Up to like & getrecommendations! Published in 2018 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2017.10.016
Abstract: Cadmium (Cd) and its compounds are highly toxic to virtually all organ systems of the mammals. Cd-induced testicular injuries have been reported in various animal species, using different protocols. The self-renewal capacity and the ability… read more here.
Keywords: bone marrow; mscs; induced testicular; damage ... See more keywords
Ethanolic extract of Moringa oleifera leaves alleviate cyclophosphamide-induced testicular toxicity by improving endocrine function and modulating cell specific gene expression in mouse testis.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2020.112922
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Moringa oleifera Lam. is known for its nutritional and ethno medicinal values due to the presence of wide array of phytochemicals with multiple biological activities. We have previously reported that ethanolic extract of… read more here.
Keywords: spermatogonial cells; moringa oleifera; testicular toxicity; expression ... See more keywords
Korean red ginseng attenuates doxorubicin-induced testicular dysfunction in rats by modulating inflammatory, oxidative, and autophagy responses
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DOI: 10.1016/j.jff.2017.12.008
Abstract: Abstract The effect of Korean red ginseng (KRG; Panax ginseng Meyer) against doxorubicin (DOX)-induced testicular inflammation was investigated. Male Sprague-Dawley rats were treated with DOX (1 mg mL−1 kg−1 week−1; intra-peritoneally) for 8 weeks, and KRG water extract (EX1; 100… read more here.
Keywords: ginseng attenuates; ginseng; red ginseng; autophagy ... See more keywords
Lycopene abrogates di‐(2‐ethylhexyl) phthalate induced testicular injury by modulating oxidative, endocrine and inflammatory changes in mice
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DOI: 10.1016/j.lfs.2018.06.009
Abstract: ABSTRACT Di (2‐ethylhexyl) phthalate (DEHP) is one of the environmental pollutants that causes testicular damage. Lycopene (LYCO), the main active carotenoid in red fruits and vegetables, has well‐known antiinflammatory and antioxidant activities. The present study… read more here.
Keywords: inflammatory; ethylhexyl phthalate; induced testicular; testicular injury ... See more keywords
Lack of beneficial effect of activated charcoal in lead induced testicular toxicity in male albino rats
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DOI: 10.1016/j.mefs.2017.02.001
Abstract: Abstract Objective: Lead is a multi-organ toxicant implicated in various diseases including testicular toxicity. In search of cheap and readily available antidote this study has investigated a beneficial role of activated charcoal in lead induced… read more here.
Keywords: activated charcoal; testicular toxicity; induced testicular; lead ... See more keywords