SKI and SMAD4 are essential for IL-21-induced Th17 differentiation.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular immunology"
DOI: 10.1016/j.molimm.2019.07.029
Abstract: Th17 cells are essential for the pathogenesis of inflammatory and autoimmune diseases. In the presence of TGF-β, the differentiation of Th17 cells can be induced by inflammatory cytokines, especially IL-6, which is mainly produced by… read more here.
Keywords: ski smad4; th17 differentiation; differentiation; induced th17 ... See more keywords
Inflammation-Induced Th17 Cells Synergize with the Inflammation-Trained Microbiota to Mediate Host Resiliency Against Intestinal Injury.
Sign Up to like & getrecommendations! Published in 2025 at "Inflammatory bowel diseases"
DOI: 10.1093/ibd/izae293
Abstract: BACKGROUND AND AIMS Inflammation can generate pathogenic Th17 cells and cause an inflammatory dysbiosis. In the context of inflammatory bowel disease (IBD), these inflammatory Th17 cells and dysbiotic microbiota may perpetuate injury to intestinal epithelial… read more here.
Keywords: inflammation induced; th17 cells; induced th17; injury ... See more keywords