Machine Learning‐Enabled Drug‐Induced Toxicity Prediction
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202413405
Abstract: Unexpected toxicity has become a significant obstacle to drug candidate development, accounting for 30% of drug discovery failures. Traditional toxicity assessment through animal testing is costly and time‐consuming. Big data and artificial intelligence (AI), especially… read more here.
Keywords: induced toxicity; toxicity prediction; drug; toxicity ... See more keywords
β‐Glucuronidase Inhibition in Drug Development: Emerging Strategies for Mitigating Drug‐Induced Toxicity and Enhancing Therapeutic Outcomes
Sign Up to like & getrecommendations! Published in 2025 at "Drug Development Research"
DOI: 10.1002/ddr.70118
Abstract: β‐glucuronidase (βG) is a critical enzyme involved in the hydrolysis of glucuronide conjugates, significantly influencing drug metabolism, detoxification processes, and enterohepatic circulation. Although essential for maintaining physiological homeostasis, dysregulated βG activity has been implicated in… read more here.
Keywords: drug induced; induced toxicity; drug; toxicity ... See more keywords
Ameliorative effect of ellagic acid and Vitamin C against malathion‐induced toxicity in testis of adult Wistar rats
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23314
Abstract: The pesticide malathion (MT), an organophosphate, is highly neurotoxic and causes cholinergic disorders as well as cytotoxicity, genotoxicity, mutagenicity, carcinogenicity and reproductive toxicity. Our purpose was to study the effect of ellagic acid (EA) and… read more here.
Keywords: induced toxicity; toxicity; testis; acid vitamin ... See more keywords
Protective Effects of Ascorbic Acid Against Cadmium‐Induced Toxicity in the Placenta and Fetus of Rats
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.70053
Abstract: This study aimed to determine the protective role of l‐ascorbic acid in a pregnant rat model of cadmium‐induced toxicity. Cadmium is a toxic heavy metal that can seriously harm placenta and fetus tissue in pregnant… read more here.
Keywords: placenta; cadmium; induced toxicity; cadmium induced ... See more keywords
Protective effect of extractive and biotechnological chondroitin in insulin amyloid and advanced glycation end product‐induced toxicity
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27153
Abstract: Glycosaminoglycans are extracellular matrix components related to several biological functions and diseases. Chondroitin sulfate is a sulphated glycosaminoglycan synthesized as part of proteoglycan molecules. They are frequently associated with amyloid deposits and possess an active… read more here.
Keywords: amyloid; chondroitin; end; toxicity ... See more keywords
Toxic Mechanisms of Fipronil in Human Astrocytes and the Protective Effect of Vitamin E on Fipronil-Induced Toxicity.
Sign Up to like & getrecommendations! Published in 2025 at "Environmental toxicology"
DOI: 10.1002/tox.24546
Abstract: Fipronil (FIP), a widely used agricultural insecticide, has raised significant concerns due to its harmful environmental residues and neurotoxic effects. Although FIP's toxicological impact has been studied in some neuronal cell models, its specific effects… read more here.
Keywords: vitamin; induced toxicity; fipronil; oxidative stress ... See more keywords
Exogenous phosphatidylcholine supplementation retrieve aluminum-induced toxicity in male albino rats
Sign Up to like & getrecommendations! Published in 2017 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-017-9151-x
Abstract: This study investigated the ameliorative potential of exogenous phosphatidylcholine (PC) against aluminum-induced toxicity in male albino rats. Four groups of rats were used for this study (N = 8): group I served as the control, group II… read more here.
Keywords: aluminum induced; phosphatidylcholine; exogenous phosphatidylcholine; serum ... See more keywords
Antioxidant and Protective Effects of Schinus terebinthifolius Raddi Against Doxorubicin-Induced Toxicity
Sign Up to like & getrecommendations! Published in 2017 at "Applied Biochemistry and Biotechnology"
DOI: 10.1007/s12010-017-2589-y
Abstract: Doxorubicin is an anticancer drug whose toxic effects on non-cancer cells are associated with increased oxidative stress. This study investigated the chemical composition, antioxidant activity of the methanolic extract of Schinus terebinthifolius Raddi leaves (MESL)… read more here.
Keywords: schinus terebinthifolius; doxorubicin induced; induced toxicity; terebinthifolius raddi ... See more keywords
The Role of SIRT1–BDNF Signaling Pathway in Fluoride-Induced Toxicity for Glial BV-2 Cells
Sign Up to like & getrecommendations! Published in 2025 at "Biological Trace Element Research"
DOI: 10.1007/s12011-024-04503-y
Abstract: Chronic fluorosis is often accompanied by neurological symptoms, leading to attention, memory and learning ability decline and causing tension, anxiety, depression, and other mental symptoms. In the present study, we analyzed the molecular mechanisms of… read more here.
Keywords: fluoride induced; sirt1 bdnf; role sirt1; induced toxicity ... See more keywords
Protective Effects of Donepezil Against Alcohol-Induced Toxicity in Cell Culture: Role of Caspase-3
Sign Up to like & getrecommendations! Published in 2018 at "Neurotoxicity Research"
DOI: 10.1007/s12640-018-9913-3
Abstract: Ethanol (EtOH) is one of the most frequently abused drugs with heavy health, economic, and societal burdens. Although moderate to low EtOH may have some neuroprotective effects, heavy EtOH consumption associated with high blood alcohol… read more here.
Keywords: caspase; etoh induced; toxicity; alcohol induced ... See more keywords
Sodium Butyrate Protects Against Ethanol-Induced Toxicity in SH-SY5Y Cell Line
Sign Up to like & getrecommendations! Published in 2021 at "Neurotoxicity Research"
DOI: 10.1007/s12640-021-00418-x
Abstract: Alcohol use disorder (AUD), brought about by excessive alcohol use, is associated with damages to several organs including the brain. Chronic excessive use of alcohol can compromise intestinal integrity, leading to changes in gut microbiota… read more here.
Keywords: sodium butyrate; toxicity; induced toxicity; cell ... See more keywords