Deep representation learning of chemical-induced transcriptional profile for phenotype-based drug discovery
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DOI: 10.1038/s41467-024-49620-3
Abstract: Artificial intelligence transforms drug discovery, with phenotype-based approaches emerging as a promising alternative to target-based methods, overcoming limitations like lack of well-defined targets. While chemical-induced transcriptional profiles offer a comprehensive view of drug mechanisms, inherent… read more here.
Keywords: induced transcriptional; drug discovery; drug; transigen ... See more keywords
Wnt/Wingless signaling promotes lipid mobilization through signal-induced transcriptional repression
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2322066121
Abstract: Significance The Wnt signaling pathway, often deregulated in cancer and other diseases, remains poorly understood in lipid metabolism, particularly lipid mobilization. This study reveals that active Wnt/Wg signaling potently reduces lipid accumulation in Drosophila adipocytes… read more here.
Keywords: wnt; transcriptional repression; induced transcriptional; wnt signaling ... See more keywords