Tailored Liposomal Nanomedicine Suppresses Incomplete Radiofrequency Ablation‐Induced Tumor Relapse by Reprogramming Antitumor Immunity
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202403979
Abstract: Radiofrequency ablation (RFA), a thermoablative treatment for small hepatocellular carcinoma (HCC), has limited therapeutic benefit for advanced HCC patients with large, multiple, and/or irregular tumors owing to incomplete RFA (iRFA) of the tumor mass. It… read more here.
Keywords: radiofrequency ablation; tumor; antitumor immunity; liposomal nanomedicine ... See more keywords
Surgical stress-induced tumor immune suppressive environment.
Sign Up to like & getrecommendations! Published in 2024 at "Carcinogenesis"
DOI: 10.1093/carcin/bgae012
Abstract: Despite significant advances in cancer treatment over the decades, surgical resection remains a prominent management approach for solid neoplasms. Unfortunately, accumulating evidence suggests that surgical stress caused by tumor resection may potentially trigger postoperative metastatic… read more here.
Keywords: surgical stress; stress; stress induced; immune ... See more keywords
First-in-Human Phase I/II Study of INCAGN01876, a Glucocorticoid-Induced Tumor Necrosis Factor Receptor Agonist, in Patients with Advanced or Metastatic Solid Tumors
Sign Up to like & getrecommendations! Published in 2025 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-24-4141
Abstract: Abstract Purpose: Glucocorticoid-induced tumor necrosis factor receptor–related protein (GITR) agonism in T cells may potentiate antitumor immune responses to immune checkpoint blockade therapy. This first-in-human, phase I/II dose escalation/expansion study assessed INCAGN01876, a humanized GITR-targeting… read more here.
Keywords: receptor; glucocorticoid induced; factor receptor; tumor necrosis ... See more keywords
Lenvatinib-Induced Tumor-Related Hemorrhages in Patients with Large Hepatocellular Carcinomas
Sign Up to like & getrecommendations! Published in 2020 at "Oncology"
DOI: 10.1159/000510911
Abstract: Introduction: Lenvatinib has been approved as a systemic therapy for patients with unresectable hepatocellular carcinoma (HCC). We recently experienced lenvatinib-induced tumor-related hemorrhage in patients with HCC. The full details of tumor-related hemorrhage as a lenvatinib-related… read more here.
Keywords: lenvatinib; lenvatinib induced; tumor related; hemorrhage ... See more keywords
Soluble glucocorticoid-induced tumor necrosis factor receptor regulates Helios expression in myasthenia gravis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-019-1916-1
Abstract: BackgroundHelios is important for functional and phenotype stability of regulatory T cells (Tregs). However, the role of Helios in autoimmune diseases and its regulation remains unclear. This study aimed to investigate the role of Helios+… read more here.
Keywords: helios tregs; glucocorticoid induced; gitr; expression ... See more keywords
Nicaraven Attenuates Postoperative Systemic Inflammatory Responses-Induced Tumor Metastasis
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Surgical Oncology"
DOI: 10.1245/s10434-019-08076-2
Abstract: Background Inflammation has been demonstrated to promote cancer metastasis. Due to the well-known systemic inflammatory responses (SIR) after major surgery, it is critical to investigate and attenuate SIR-induced tumor metastasis of cancer patients suffering surgical… read more here.
Keywords: metastasis; tumor metastasis; inflammatory responses; induced tumor ... See more keywords
Three unconventional maxims in the natural selection of cancer cells: Generation of induced tumor-suppressing cells (iTSCs)
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.79155
Abstract: Induced tumor-suppressing cells (iTSCs) can be generated from cancer and non-cancer cells. Here, three paradoxical maxims for the action of iTSCs are reviewed: the secretion of tumor-suppressing proteins, their role as a “double-edged” sword, and… read more here.
Keywords: suppressing cells; cancer; tumor suppressing; cancer cells ... See more keywords