Structural basis of urea‐induced unfolding of Fasciola gigantica glutathione S‐transferase
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27253
Abstract: Glutathione S‐transferases (GSTs) are enzymes that are involved in the detoxification of harmful electrophilic endogenous and exogenous compounds by conjugating with glutathione (GSH). The liver fluke GSTs have multifunctional roles in the host–parasite interaction, such… read more here.
Keywords: fasciola gigantica; urea induced; induced unfolding; glutathione ... See more keywords
Mechano-Induced Unfolding of Von Willebrand Factor: A Clinical Example of Protein Destabilization
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.2653
Abstract: Protein stability can be quantified, in experiments or simulations, by monitoring changes in free energy induced by single amino-acid mutations relative to changes imposed by the same mutation in a reference unfolded peptide. We here… read more here.
Keywords: protein; cleavage; induced unfolding; destabilization ... See more keywords
Investigation of guanidinium chloride-induced unfolding pathway of sphingosine kinase 1.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.01.023
Abstract: Sphingosine kinase 1 (SphK1) is a lipid kinase which plays vital role in the regulation of varieties of biological processes including, cell growth, apoptosis and mitogenesis. In the present study, we investigated the guanidinium chloride… read more here.
Keywords: sphingosine kinase; guanidinium chloride; kinase; induced unfolding ... See more keywords
Collision-Induced Unfolding of Partially Metalated Metallothionein-2A: Tracking Unfolding Reactions of Gas-Phase Ions.
Sign Up to like & getrecommendations! Published in 2018 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.8b01622
Abstract: Metallothioneins (MTs) constitute a group of intrinsically disordered proteins that exhibit extreme diversity in structure, biological functionality, and metal ion specificity. Structures of coordinatively saturated metalated MTs have been extensively studied, but very limited structural… read more here.
Keywords: gas phase; induced unfolding; collision induced; partially metalated ... See more keywords
Mechanistic Insights into the Ligand-Induced Unfolding of an RNA G-Quadruplex.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c11248
Abstract: The cationic porphyrin TMPyP4 is a well-established DNA G-quadruplex (G4) binding ligand that can stabilize different topologies via multiple binding modes. However, TMPyP4 can have both a stabilizing and destabilizing effect on RNA G4 structures.… read more here.
Keywords: ligand induced; induced unfolding; rna; ligand ... See more keywords
Comparing Selected-Ion Collision Induced Unfolding with All Ion Unfolding Methods for Comprehensive Protein Conformational Characterization.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Society for Mass Spectrometry"
DOI: 10.1021/jasms.2c00004
Abstract: Structural analysis by native ion mobility-mass spectrometry provides a direct means to characterize protein interactions, stability, and other biophysical properties of disease-associated biomolecules. Such information is often extracted from collision-induced unfolding (CIU) experiments, performed by… read more here.
Keywords: induced unfolding; charge state; charge; ion unfolding ... See more keywords