Estrogen increases expression of vascular alpha 2C adrenoceptor through the cAMP/Epac/JNK/AP-1 pathway and potentiates cold-induced vasoconstriction.
Sign Up to like & getrecommendations! Published in 2020 at "Vascular pharmacology"
DOI: 10.1016/j.vph.2020.106690
Abstract: Cutaneous cold-induced vasoconstriction is a normal physiological reaction mediated by alpha 2C-adrenergic receptors (α2C-ARs) expressed in vascular smooth muscle cells (VSMCs). When this reaction is exaggerated, Raynaud's phenomenon (RP) ensues. RP is more prevalent in… read more here.
Keywords: induced vasoconstriction; jnk; cold induced; estrogen ... See more keywords
GDM enhanced acetylcholine induced vasoconstriction in human umbilical vein via CHRM3 and CACNA1C upregulation linked to promoter hypomethylation
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-10576-z
Abstract: Intrauterine exposure to hyperglycemia increases the risk of hypertension disorders in the offspring. Vascular dysfunction has a critical role in hypertension development. This study aimed to investigate the effects of GDM on human umbilical vein… read more here.
Keywords: gdm; induced vasoconstriction; chrm3 cacna1c; inhibitor ... See more keywords