Biomimetic Melanosomes Promote Orientation-Selective Delivery and Melanocyte Pigmentation in the H2O2-Induced Vitiligo Mouse Model.
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DOI: 10.1021/acsnano.1c05321
Abstract: Extremely limited drug retention and depigmentation represent the greatest barriers against vitiligo treatment advancement. Here, inspired by biological melanosomes, the primary melanin transporter, we developed biomimetic melanosomes to combat reactive oxygen species (ROS)-mediated melanocyte damage… read more here.
Keywords: melanin; induced vitiligo; h2o2 induced; biomimetic melanosomes ... See more keywords
Treatment of Checkpoint Inhibitor-Induced Vitiligo in a Patient With Metastatic Renal Cell Cancer.
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DOI: 10.1097/der.0000000000000670
Abstract: To the Editor: Although immune checkpoint inhibitors (ICIs) were originally used for metastatic melanoma, their efficacy has popularized their use in nonmelanomamalignancies. Immune checkpoint inhibitors include anti–cytotoxic T-lymphocyte–associated protein 4 (eg, ipilimumab, tremelimumab) and anti–programmed… read more here.
Keywords: renal cell; treatment; cancer; cell ... See more keywords
Pembrolizumab‐induced vitiligo in a patient with lung adenocarcinoma: A case report
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DOI: 10.1111/bcp.14663
Abstract: Pembrolizumab is an immune checkpoint inhibitor designed to block the interaction between programmed cell death‐1 and programmed cell death‐ligands 1 and 2. It shows efficacy in the treatment of patients with advanced nonsmall‐cell lung cancer,… read more here.
Keywords: vitiligo patient; induced vitiligo; pembrolizumab induced; pembrolizumab ... See more keywords
Nivolumab induced vitiligo-like lesions in a patient with metastatic squamous cell carcinoma of the lung.
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DOI: 10.21037/jtd.2018.05.104
Abstract: Nivolumab, a fully humanized monoclonal IgG4 antibody blocking programmed cell death-1 (PD-1), has demonstrated improved survival over docetaxel in previously treated patients with advanced non-small cell lung cancer (NSCLC) (1,2). Vitiligo-like depigmentation is a well… read more here.
Keywords: induced vitiligo; like lesions; nivolumab induced; vitiligo like ... See more keywords