Loss of a Negative Regulator of mTORC1 Induces Aerobic Glycolysis and Altered Fiber Composition in Skeletal Muscle
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DOI: 10.1016/j.celrep.2018.04.058
Abstract: SUMMARY The conserved GATOR1 complex consisting of NPRL2-NPRL3-DEPDC5 inhibits mammalian target of rapamycin complex 1 (mTORC1) in response to amino acid insufficiency. Here, we show that loss of NPRL2 and GATOR1 function in skeletal muscle… read more here.
Keywords: skeletal muscle; altered fiber; muscle; mtorc1 ... See more keywords