Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling
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DOI: 10.1038/s41467-017-02002-4
Abstract: Mutations in PIK3CA are very frequent in cancer and lead to sustained PI3K pathway activation. The impact of acute expression of mutant PIK3CA during early stages of malignancy is unknown. Using a mouse model to… read more here.
Keywords: tolerance; genome doubling; induces centrosome; genome ... See more keywords