VHL Inactivation in Precancerous Kidney Cells Induces an Inflammatory Response via ER Stress-Activated IRE1α Signaling.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer research"
DOI: 10.1158/0008-5472.can-16-3196
Abstract: Mutations and epigenetic inactivation of the tumor suppressor gene von Hippel-Lindau (VHL) are major causes of clear-cell renal cell carcinoma (ccRCC) that may originate from chronic inflammation. However, the role of VHL loss of function… read more here.
Keywords: kidney cells; response; induces inflammatory; inactivation ... See more keywords
Contact with Cancer Cells Induces Inflammatory Pathways in Fibroblasts.
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DOI: 10.1158/2159-8290.cd-rw2020-088
Abstract: Transcytosis from cancer cells into fibroblasts triggered the cGAS-STING pathway. read more here.
Keywords: cancer cells; cells induces; cancer; induces inflammatory ... See more keywords