Cholesterol burden in the liver induces mitochondrial dynamic changes and resistance to apoptosis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27474
Abstract: Non‐alcoholic fatty liver disease (NAFLD) encompasses a broad spectrum of histopathological changes ranging from non‐inflammatory intracellular fat deposition to non‐alcoholic steatohepatitis (NASH), which may progress into hepatic fibrosis, cirrhosis, or hepatocellular carcinoma. Recent data suggest… read more here.
Keywords: liver induces; induces mitochondrial; cholesterol; liver ... See more keywords
Farnesol induces mitochondrial/peroxisomal biogenesis and thermogenesis by enhancing the AMPK signaling pathway in vivo and in vitro.
Sign Up to like & getrecommendations! Published in 2020 at "Pharmacological research"
DOI: 10.1016/j.phrs.2020.105312
Abstract: Thermogenic activation of brown adipose tissue has been considered as an obesity treatment strategy that consumes energy. In this study, we investigated whether farnesol in vivo and in vitro models induces thermogenesis and affect the… read more here.
Keywords: vivo vitro; farnesol; induces mitochondrial; farnesol induces ... See more keywords
Mitochondrial Alkbh1 localizes to mtRNA granules and its knockdown induces the mitochondrial UPR in humans and C. elegans
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cell Science"
DOI: 10.1242/jcs.223891
Abstract: ABSTRACT The Fe(II) and 2-oxoglutarate-dependent oxygenase Alkb homologue 1 (Alkbh1) has been shown to act on a wide range of substrates, like DNA, tRNA and histones. Thereby different enzymatic activities have been identified including, among… read more here.
Keywords: alkbh1; mitochondrial upr; knockdown induces; microscopy ... See more keywords
Matairesinol Induces Mitochondrial Dysfunction and Exerts Synergistic Anticancer Effects with 5-Fluorouracil in Pancreatic Cancer Cells
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DOI: 10.3390/md20080473
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive types of cancer and exhibits a devastating 5-year survival rate. The most recent procedure for the treatment of PDAC is a combination of several conventional… read more here.
Keywords: pancreatic cancer; matairesinol induces; induces mitochondrial; exerts synergistic ... See more keywords