Hypoxia‐Inducible Factor 1 Alpha–Mediated RelB/APOBEC3B Down‐regulation Allows Hepatitis B Virus Persistence
Sign Up to like & getrecommendations! Published in 2021 at "Hepatology"
DOI: 10.1002/hep.31902
Abstract: Therapeutic strategies against HBV focus, among others, on the activation of the immune system to enable the infected host to eliminate HBV. Hypoxia‐inducible factor 1 alpha (HIF1α) stabilization has been associated with impaired immune responses.… read more here.
Keywords: factor alpha; inducible factor; hypoxia inducible;
The role of hypoxia‐inducible factor‐2 alpha in angiogenesis
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DOI: 10.1002/jcp.26805
Abstract: Angiogenesis is a key enabling feature of mammalian embryonic development and tumor progression, which provides oxygen and nutrients that are required for vessel growth and tumor cell growth, respectively. Hypoxia is a driver of this… read more here.
Keywords: angiogenesis; role hypoxia; inducible factor; factor alpha ... See more keywords
Oxidized low‐density lipoprotein suppresses mouse granulosa cell differentiation through disruption of the hypoxia‐inducible factor 1 pathway
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Reproduction and Development"
DOI: 10.1002/mrd.22933
Abstract: Obesity predisposes women to reproductive disorders. One symptom of obesity in women is higher levels of oxidized Low‐density lipoprotein (oxLDL) in serum and preovulatory follicles. The present study was designed to test the hypothesis that… read more here.
Keywords: oxidized low; density lipoprotein; inducible factor; low density ... See more keywords
Hypoxia-inducible factor 1α protects peripheral sensory neurons from diabetic peripheral neuropathy by suppressing accumulation of reactive oxygen species.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-018-1707-9
Abstract: Diabetic peripheral neuropathy (DPN) is one of the most common diabetic complications. Mechanisms underlying nerve damage and sensory loss following metabolic dysfunction remain largely unclear. Recently, hyperglycemia-induced mitochondrial dysfunction and the generation of reactive oxygen… read more here.
Keywords: inducible factor; hif1; sensory neurons; hyperglycemia ... See more keywords
Hypoxia-inducible factor-1α in Antarctic notothenioids contains a polyglutamine and glutamic acid insert that varies in length with phylogeny
Sign Up to like & getrecommendations! Published in 2017 at "Polar Biology"
DOI: 10.1007/s00300-017-2164-6
Abstract: The long evolution of the Antarctic perciform suborder of Notothenioidei in the icy, oxygen-rich waters of the Southern Ocean may have reduced selective pressure to maintain a hypoxic response. To test this hypothesis, cDNA of… read more here.
Keywords: hif; amino acids; inducible factor; contains polyglutamine ... See more keywords
Inhibition of hypoxia-inducible factor-1α alleviates acinar cell necrosis in a mouse model of acute pancreatitis.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.07.043
Abstract: Hypoxia-inducible factor-1α (Hif1α) is activated in hypoxia and is closely related to oxidative stress, immunity and cell metabolism. Recently, it is reported that Hif1α is involved in atherosclerosis, ischemia-reperfusion (I/R) injury, alcoholic liver disease and… read more here.
Keywords: acute pancreatitis; hif1; inducible factor; hypoxia inducible ... See more keywords
β Cell Hypoxia-Inducible Factor-1 α Is Required for the Prevention of Type 1 Diabetes
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DOI: 10.1016/j.celrep.2019.04.086
Abstract: SUMMARY The development of autoimmune disease type 1 diabetes (T1D) is determined by both genetic background and environmental factors. Environmental triggers include RNA viruses, particularly coxsackie-virus (CV), but how they induceT1D is not understood. Here,… read more here.
Keywords: inducible factor; type diabetes; factor; cell ... See more keywords
Fracture repair by IOX2: Regulation of the hypoxia inducible factor-1α signaling pathway and BMSCs.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2022.174864
Abstract: The treatment of fracture delayed union and nonunion has become a challenging problem. Hypoxia inducible factor-1α (HIF-1α) is reported to be a key factor in fracture healing, and is degraded by hydroxylation of prolyl hydroxylase… read more here.
Keywords: inducible factor; hif; fracture; hypoxia inducible ... See more keywords
Hypoxia-inducible factor-1: A potential pharmacological target to manage psoriasis.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106689
Abstract: Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric transcriptional factor and is composed of HIF-1α and HIF-1β subunits. An increase in the levels of HIF-1α in the psoriatic lesions and the serum of psoriatic patients has been… read more here.
Keywords: hif; inducible factor; increase; psoriasis ... See more keywords
Activation of Hypoxia-Inducible Factor Signaling Modulates the RNA Protein Interactome in Caenorhabditis elegans
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DOI: 10.1016/j.isci.2019.11.039
Abstract: Summary The cellular response to hypoxia is crucial to organismal survival, and hypoxia-inducible factors (HIF) are the key mediators of this response. HIF-signaling is central to many human diseases and mediates longevity in the nematode.… read more here.
Keywords: inducible factor; caenorhabditis elegans; activation hypoxia; hypoxia ... See more keywords
Regulation of hypoxia-inducible factor-1α in human buccal mucosal fibroblasts stimulated with arecoline.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the Formosan Medical Association = Taiwan yi zhi"
DOI: 10.1016/j.jfma.2017.02.019
Abstract: Hypoxia-inducible factor (HIF)-1α is consistently and dramatically upregulated in a variety of fibrotic diseases. The aim of this study was to compare HIF-1α expression from fibroblasts derived from human normal buccal mucosa and oral submucous… read more here.
Keywords: mucosal fibroblasts; buccal mucosal; inducible factor; expression ... See more keywords