Hypoxia and hypoxia-inducible factors in neuroblastoma
Sign Up to like & getrecommendations! Published in 2017 at "Cell and Tissue Research"
DOI: 10.1007/s00441-017-2701-1
Abstract: Hypoxia (i.e., low oxygen levels) is a known feature of aggressive tumors. Cells, including tumor cells, respond to conditions of insufficient oxygen by activating a transcriptional program mainly driven by hypoxia-inducible factors (HIF)-1 and HIF-2.… read more here.
Keywords: hif; hypoxia hypoxia; hif hif; inducible factors ... See more keywords
Hypoxia-inducible factors promote breast cancer stem cell specification and maintenance in response to hypoxia or cytotoxic chemotherapy.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in cancer research"
DOI: 10.1016/bs.acr.2018.11.001
Abstract: Clinical studies have revealed that breast cancers contain regions of intratumoral hypoxia (reduced oxygen availability), which activates hypoxia-inducible factors (HIFs). The relationship between intratumoral hypoxia, distant metastasis and cancer mortality has been well established. A… read more here.
Keywords: chemotherapy; breast; cancer; inducible factors ... See more keywords
Esterification promotes the intracellular accumulation of roxadustat, an activator of hypoxia-inducible factors, to extend its effective duration.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2022.114939
Abstract: Kidney injury often causes anemia due to a lack of production of the erythroid growth factor erythropoietin (EPO) in the kidneys. Roxadustat is one of the first oral medicines inducing EPO production in patients with… read more here.
Keywords: hypoxia inducible; effective duration; esterification; inducible factors ... See more keywords
An intimate crosstalk between iron homeostasis and oxygen metabolism regulated by the hypoxia‐inducible factors (HIFs)
Sign Up to like & getrecommendations! Published in 2019 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.07.018
Abstract: ABSTRACT Oxygen and iron are among the most abundant elements and have significant roles in human biology. Iron is essential for oxygen transport and is a component of molecular O2‐carrying proteins, such as hemoglobin and… read more here.
Keywords: homeostasis; oxygen; biology; inducible factors ... See more keywords
Hypoxia-inducible factors: roles in cardiovascular disease progression, prevention, and treatment.
Sign Up to like & getrecommendations! Published in 2022 at "Cardiovascular research"
DOI: 10.1093/cvr/cvac089
Abstract: Hypoxia-inducible factors (HIF)-1 and HIF-2 are master regulators of oxygen homeostasis that regulate the expression of thousands of genes in order to match O2 supply and demand. A large body of experimental data links HIF… read more here.
Keywords: inducible factors; disease; cardiovascular disease; hypoxia inducible ... See more keywords
The Landscape of Interactions between Hypoxia-Inducible Factors and Reactive Oxygen Species in the Gastrointestinal Tract
Sign Up to like & getrecommendations! Published in 2021 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2021/8893663
Abstract: The gastrointestinal tract (GT) is the major organ involved in digestion, absorption, and immunity, which is prone to oxidative destruction by high levels of reactive oxygen species (ROS) from luminal oxidants, such as food, drugs,… read more here.
Keywords: gastrointestinal tract; oxygen; reactive oxygen; oxygen species ... See more keywords
Hypoxia-Inducible Factors in Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Research"
DOI: 10.1158/0008-5472.can-21-3780
Abstract: Low oxygen concentrations (hypoxia) are detrimental to most species on Earth; thus, cells have evolved with adaptations allowing them to withstand transient hypoxia. As with other survival pathways, cancer cells have co-opted these mechanisms to… read more here.
Keywords: hypoxia; hypoxia inducible; factors cancer; inducible factors ... See more keywords
Editorial: Role of hypoxia-inducible factors in metabolic immune cell adaptation during sepsis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1194504
Abstract: COPYRIGHT © 2023 del Fresno, Schulte and LópezCollazo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted,… read more here.
Keywords: metabolic immune; inducible factors; role hypoxia; hypoxia inducible ... See more keywords
Targeting hypoxia-inducible factors for breast cancer therapy: A narrative review
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1064661
Abstract: Hypoxia-inducible factors (HIFs), central regulators for cells to adapt to low cellular oxygen levels, are often overexpressed and activated in breast cancer. HIFs modulate the primary transcriptional response of downstream pathways and target genes in… read more here.
Keywords: inducible factors; hypoxia inducible; breast cancer; cancer therapy ... See more keywords
Clinical Potential of Hypoxia Inducible Factors Prolyl Hydroxylase Inhibitors in Treating Nonanemic Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.837249
Abstract: Hypoxia inducible factors (HIFs) and their regulatory hydroxylases the prolyl hydroxylase domain enzymes (PHDs) are the key mediators of the cellular response to hypoxia. HIFs are normally hydroxylated by PHDs and degraded, while under hypoxia,… read more here.
Keywords: prolyl hydroxylase; inducible factors; hypoxia inducible; hypoxia ... See more keywords
Hypoxia and Hypoxia-Inducible Factors in Lymphedema
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.851057
Abstract: Lymphedema is a chronic inflammatory disorder characterized by edema, fat deposition, and fibrotic tissue remodeling. Despite significant advances in lymphatic biology research, our knowledge of lymphedema pathology is incomplete. Currently, there is no approved pharmacological… read more here.
Keywords: factors lymphedema; inducible factors; hypoxia inducible; hypoxia ... See more keywords