GLI1-Inducible Glucuronidation Targets a Broad Spectrum of Drugs.
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DOI: 10.1021/acschembio.8b01118
Abstract: Cancer therapies are plagued by resistance. Previously, we discovered a novel form of cancer drug resistance where the Glioma-associated protein 1 (GLI1) elevates UGT1A glucuronidation enzymes, thereby glucuronidating cytarabine and ribavirin, leading to resistance in… read more here.
Keywords: gli1 inducible; glucuronidation; inducible glucuronidation; resistance ... See more keywords