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   Articles with "inducible kinases" as a keyword



Salt inducible kinases 2 and 3 are required for thymic T cell development

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recommendations! Published in 2021 at "Scientific Reports"

DOI: 10.1038/s41598-021-00986-0

Abstract: Salt Inducible Kinases (SIKs), of which there are 3 isoforms, are established to play roles in innate immunity, metabolic control and neuronal function, but their role in adaptive immunity is unknown. To address this gap,… read more here.

Keywords: cell development; salt inducible; inducible kinases; thymic cell ... See more keywords

The Role of the Salt-Inducible Kinases in the Endocrine Glands.

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recommendations! Published in 2025 at "Endocrinology"

DOI: 10.1210/endocr/bqaf100

Abstract: The salt-inducible kinases (SIKs), a family of serine/threonine kinases, are emerging endocrine regulators. The three isoforms, SIK1, SIK2, and SIK3, compose a subfamily of the AMPK-related kinases. The SIKs have multiple conserved protein kinase A… read more here.

Keywords: salt inducible; role salt; inducible kinases; endocrine glands ... See more keywords

Salt-inducible kinases (SIK) inhibition reduces RANKL-induced osteoclastogenesis

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recommendations! Published in 2017 at "PLoS ONE"

DOI: 10.1371/journal.pone.0185426

Abstract: Osteoclasts are large multinucleated cells responsible for bone resorption. Excessive inflammatory activation of osteoclasts leads to bony erosions, which are the hallmark of several diseases such as rheumatoid arthritis (RA). Salt-inducible kinases (SIK) constitute a… read more here.

Keywords: sik inhibition; inhibition; salt inducible; inducible kinases ... See more keywords

Understanding the roles of salt-inducible kinases in cardiometabolic disease

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recommendations! Published in 2024 at "Frontiers in Physiology"

DOI: 10.3389/fphys.2024.1426244

Abstract: Salt-inducible kinases (SIKs) are serine/threonine kinases of the adenosine monophosphate-activated protein kinase family. Acting as mediators of a broad array of neuronal and hormonal signaling pathways, SIKs play diverse roles in many physiological and pathological… read more here.

Keywords: salt inducible; disease; inducible kinases; phosphorylation ... See more keywords