Salt inducible kinases 2 and 3 are required for thymic T cell development
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-00986-0
Abstract: Salt Inducible Kinases (SIKs), of which there are 3 isoforms, are established to play roles in innate immunity, metabolic control and neuronal function, but their role in adaptive immunity is unknown. To address this gap,… read more here.
Keywords: cell development; salt inducible; inducible kinases; thymic cell ... See more keywords
Salt-inducible kinases (SIK) inhibition reduces RANKL-induced osteoclastogenesis
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DOI: 10.1371/journal.pone.0185426
Abstract: Osteoclasts are large multinucleated cells responsible for bone resorption. Excessive inflammatory activation of osteoclasts leads to bony erosions, which are the hallmark of several diseases such as rheumatoid arthritis (RA). Salt-inducible kinases (SIK) constitute a… read more here.
Keywords: sik inhibition; inhibition; salt inducible; inducible kinases ... See more keywords