Nuclear actin regulates inducible transcription by enhancing RNA polymerase II clustering
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DOI: 10.1126/sciadv.aay6515
Abstract: Nuclear actin promotes the formation of inducible transcription factory, as a general mechanism of the rapid response to stimuli. Gene expression in response to stimuli underlies many fundamental processes. However, how transcription is regulated under… read more here.
Keywords: response; actin; inducible transcription; rna polymerase ... See more keywords
Hypoxia-inducible transcription factor-1α inhibition by topotecan protects against lipopolysaccharide-induced inflammation and apoptosis of cardiomyocytes
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DOI: 10.1186/s12938-021-00923-2
Abstract: Background Myocarditis, an inflammatory disease of the myocardium, is a serious hazard to human life due to the expansion of inflammatory lesions in the myocardium. The aim of this study was to investigate the role… read more here.
Keywords: inhibition topotecan; inducible transcription; transcription factor; factor ... See more keywords