Tumor‐targeted and microenvironment‐activatable iron‐based nMOF for synergistic inducing ferroptosis
Sign Up to like & getrecommendations! Published in 2024 at "Applied Organometallic Chemistry"
DOI: 10.1002/aoc.7456
Abstract: Ferroptosis is a new form of cell death that relies on iron and involves an imbalance of intracellular reactive oxygen species (ROS), which is expected to help alleviate bottlenecks in tumor treatment. Herein, a sorafenib‐loaded… read more here.
Keywords: iron; inducing ferroptosis; ferroptosis; based nmof ... See more keywords
ARID1A loss enhances sensitivity to c-MET inhibition by dual targeting of GPX4 and iron homeostasis, inducing ferroptosis
Sign Up to like & getrecommendations! Published in 2025 at "Cell Death and Differentiation"
DOI: 10.1038/s41418-025-01510-x
Abstract: ARID1A, a subunit of the SWI/SNF chromatin-remodeling complex, functions as a tumor suppressor in various cancer types. Owing to its high frequency of inactivating mutations, ARID1A has emerged as a promising target for the development… read more here.
Keywords: iron; arid1a loss; inducing ferroptosis; crc ... See more keywords
Konjac Glucomannan, In Combination With Cisplatin, Suppresses Lymphoma Malignant Progression By Inducing Ferroptosis.
Sign Up to like & getrecommendations! Published in 2023 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520623666230529160837
Abstract: INTRODUCTION Although formerBurkitt lymphoma (BL) chemotherapies significantly enhanced clinical outcomes, chemoresistance may result in chemotherapy failures with poor prognosis. Therefore, novel strategies are urgently demanded for drug-resistant BL patients. Emerging studies showed that konjac glucomannan… read more here.
Keywords: konjac glucomannan; inducing ferroptosis; lymphoma malignant; suppresses lymphoma ... See more keywords
Inducing ferroptosis has the potential to overcome therapy resistance in breast cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1038225
Abstract: Breast cancer is the most common type of malignancy among women. Due to the iron-dependent character of breast cancer cells, they are more sensitive to ferroptosis compared to normal cells. It is possible to reverse… read more here.
Keywords: inducing ferroptosis; breast cancer; resistance; cancer ... See more keywords
Scutellaria barbata Inhibits Hepatocellular Carcinoma Tumorigenicity by Inducing Ferroptosis of Hepatocellular Carcinoma Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.693395
Abstract: Ferroptosis is caused by accumulation of iron-dependent lipid peroxidation, which is characterized by reduction in cell volume and increase in mitochondrial membrane density. Studies have shown that ferroptosis contributes to the development and progression of… read more here.
Keywords: hepatocellular carcinoma; inducing ferroptosis; hcc; ferroptosis ... See more keywords
PROTAC-Surufatinib Suppresses Pancreatic Neuroendocrine Neoplasms Progression by Inducing Ferroptosis through Inhibiting WNT/β-catenin Pathway Mediated by HMOX1
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.106357
Abstract: The small-molecule targeting drug Surufatinib is a new strategy for pancreatic neuroendocrine neoplasms (pNENs). However, the adverse reactions of Surufatinib should not be ignored in clinical practice. Based on PROTAC technology, we developed a novel… read more here.
Keywords: progression; inducing ferroptosis; hmox1; wnt catenin ... See more keywords