eIF4A1 Inhibitor Suppresses Hyperactive mTOR-Associated Tumors by Inducing Necroptosis and G2/M Arrest
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DOI: 10.3390/ijms23136932
Abstract: Aberrantly activated mechanistic target of rapamycin (mTOR) signaling pathway stimulates translation initiation/protein synthesis and eventually causes tumors. Targeting these processes thus holds potential for treating mTOR-associated diseases. We tested the potential of eFT226, a sequence-selective… read more here.
Keywords: hyperactive mtor; inhibitor; mtor associated; inducing necroptosis ... See more keywords