Induction of apically mistrafficked epiregulin disrupts epithelial polarity via aberrant EGFR signaling.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cell science"
DOI: 10.1242/jcs.255927
Abstract: In polarized MDCK cells, disruption of the tyrosine-based YXXΦ basolateral trafficking motif (Y156A) in the EGFR ligand, epiregulin (EREG), results in its apical mistrafficking and transformation in vivo. However, mechanism(s) underlying these dramatic effects are… read more here.
Keywords: egfr; induction apically; mdck cells; polarity ... See more keywords