High‐level induction of fetal haemoglobin by pomalidomide in β‐thalassaemia/HbE erythroid progenitor cells
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DOI: 10.1111/bjh.16670
Abstract: Sally Killick Aimee Jackson Helen C. Coulthard Christina Yap Emma Das-Gupta Dudley J. Pennell John Porter David Bowen Dominic Culligan Royal Bournemouth and Christchurch NHS Foundation Trust, Cancer Research UK Clinical Trials Unit (CRCTU), University… read more here.
Keywords: haemoglobin pomalidomide; fetal haemoglobin; high level; level induction ... See more keywords
Induction of fetal hemoglobin: Lentiviral shRNA knockdown of HBS1L in β0-thalassemia/HbE erythroid cells
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DOI: 10.1371/journal.pone.0281059
Abstract: Imbalanced globin chain output contributes to thalassemia pathophysiology. Hence, induction of fetal hemoglobin in β-thalassemia and other β-hemoglobinopathies are of continuing interest for therapeutic approaches. Genome-wide association studies have identified three common genetic loci: namely… read more here.
Keywords: induction fetal; fetal hemoglobin; thalassemia hbe; knockdown hbs1l ... See more keywords
Induction of Fetal Hemoglobin by Introducing Natural Hereditary Persistence of Fetal Hemoglobin Mutations in the γ-Globin Gene Promoters for Genome Editing Therapies for β-Thalassemia
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DOI: 10.3389/fgene.2022.881937
Abstract: Reactivation of γ-globin expression is a promising therapeutic approach for β-hemoglobinopathies. Here, we propose a novel Cas9/AAV6-mediated genome editing strategy for the treatment of β-thalassemia: Natural HPFH mutations −113A > G, −114C > T, −117G>A,… read more here.
Keywords: genome editing; hemoglobin introducing; thalassemia; induction fetal ... See more keywords
Pharmacological Induction of Fetal Hemoglobin in β-Thalassemia and Sickle Cell Disease: An Updated Perspective
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DOI: 10.3390/ph15060753
Abstract: A significant amount of attention has recently been devoted to the mechanisms involved in hemoglobin (Hb) switching, as it has previously been established that the induction of fetal hemoglobin (HbF) production in significant amounts can… read more here.
Keywords: thalassemia sickle; cell disease; induction fetal; fetal hemoglobin ... See more keywords