High-performance PBPK model for predicting CYP3A4 induction-mediated drug interactions: a refined and validated approach
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2025.1521068
Abstract: Introduction The cytochrome P450 enzyme 3A4 (CYP3A4) mediates numerous drug-drug interactions (DDIs) by inducing the metabolism of co-administered drugs, which can result in reduced therapeutic efficacy or increased toxicity. This study developed and validated a… read more here.
Keywords: induction mediated; cyp3a4 induction; pbpk model; drug ... See more keywords
Defective Induction of IL-27-Mediated Immunoregulation by Myeloid DCs in Multiple Sclerosis
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24098000
Abstract: The purpose of this study was to examine whether myeloid dendritic cells (mDCs) from patients with multiple sclerosis (MS) and healthy controls (HCs) become similarly tolerogenic when exposed to IL-27 as this may represent a… read more here.
Keywords: induction mediated; sclerosis; mdcs; defective induction ... See more keywords